| Full text | |
| Author(s): |
Menezes, Ana Paula
;
Murillo, Ana Milena
;
de Castro, Camila Gachet
;
Bellini, Natalia Karla
;
Tosi, Luiz Ricardo Orsini
;
Thiemann, Otavio Henrique
;
Elias, Maria Carolina
;
Silber, Ariel Mariano
;
da Cunha, Julia Pinheiro Chagas
Total Authors: 9
|
| Document type: | Journal article |
| Source: | Trends in Parasitology; v. 39, n. 8, p. 14-pg., 2023-08-01. |
| Abstract | |
Epigenetic marks enable cells to acquire new biological features that favor their adaptation to environmental changes. These marks are chemical modifications on chromatin-associated proteins and nucleic acids that lead to changes in the chromatin landscape and may eventually affect gene expression. The chemical tags of these epigenetic marks are comprised of intermediate cellular metabo-lites. The number of discovered associations between metabolism and epige-netics has increased, revealing how environment influences gene regulation and phenotype diversity. This connection is relevant to all organisms but under -appreciated in digenetic parasites, which must adapt to different environments as they progress through their life cycles. This review speculates and proposes associations between epigenetics and metabolism in trypanosomes, which are protozoan parasites that cause human and livestock diseases. (AU) | |
| FAPESP's process: | 21/12469-0 - Genome-wide approaches to reveal epigenomic structure in trypanosomes subjected to metabolic states changes and during cell cycle |
| Grantee: | Camila Gachet de Castro |
| Support Opportunities: | Scholarships in Brazil - Post-Doctoral |
| FAPESP's process: | 18/14432-3 - A network for an integrative biology in neglected diseases: bridging epigenetics, metabolism and cell cycle in pathogenic trypanosomatids |
| Grantee: | Ariel Mariano Silber |
| Support Opportunities: | Research Projects - Thematic Grants |
| FAPESP's process: | 18/15553-9 - Going deeper into Trypanosoma cruzi chromatin regulation: identifying new players and quizzing its impact on a potential transcription control |
| Grantee: | Julia Pinheiro Chagas da Cunha |
| Support Opportunities: | Research Grants - Young Investigators Grants - Phase 2 |
| FAPESP's process: | 21/03219-0 - Interrogation of a potential transcription regulation in Trypanosoma cruzi by evaluation of nascent transcripts genome-widely |
| Grantee: | Natália Karla Bellini |
| Support Opportunities: | Scholarships in Brazil - Post-Doctoral |
| FAPESP's process: | 19/21354-1 - Chasing for chromatine-associated proteins and histone PTMs patterns associated to cell stages and metabolic states in trypanosomes |
| Grantee: | Ana Paula de Jesus Menezes |
| Support Opportunities: | Scholarships in Brazil - Post-Doctoral |
| FAPESP's process: | 20/00694-6 - How DNA replication contributes for the success of infection caused by Trypanosoma cruzi |
| Grantee: | Maria Carolina Quartim Barbosa Elias Sabbaga |
| Support Opportunities: | Research Projects - Thematic Grants |