Comparative Study of Chemical Composition and Biological Activity of Yellow, Green, Brown, and Red Brazilian Propolis

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Machado, Christiane Schineider ; Mokochinski, Joao Benhur ; de Lira, Tatiana Onofre ; Evangelista de Oliveira, Fatima de Cassia ; Cardoso, Magda Vieira ; Ferreira, Roseane Guimaraes ; Helena Frankland Sawaya, Alexandra Christine ; Ferreira, Antonio Gilberto ; Pessoa, Claudia ; Cuesta-Rubio, Osmany ; Monteiro, Marta Chagas ; de Campos, Monica Soares ; Torres, Yohandra Reyes

• Document type: Journal article
• Source: Evidence-based Complementary and Alternative Medicine; v. 2016, p. 11-pg., 2016-01-01.

Abstract

The chemical composition and biological activity of a sample of yellow propolis from Mato Grosso do Sul, Brazil (EEP-Y MS), were investigated for the first time and compared with green, brown, and red types of Brazilian propolis and with a sample of yellow propolis from Cuba. Overall, EEP-Y MS had different qualitative chemical profiles, as well as different cytotoxic and antimicrobial activities when compared to the other types of propolis assessed in this study and it is a different chemotype of Brazilian propolis. Absence of phenolic compounds and the presence of mixtures of aliphatic compounds in yellow propolis were determined by analysing H-1-NMR spectra and fifteen terpenes were identified by GC-MS. EEP-Y MS showed cytotoxic activity against human tumour strain OVCAR-8 but was not active against Gram-negative or Gram-positive bacteria. Our results confirm the difficulty of establishing a uniform quality standard for propolis from diverse geographical origins. The most appropriate pharmacological applications of yellow types of propolis must be further investigated. (AU)

• FAPESP's process: 13/21306-0 - DEVELOPMENT OF ANALYTICAL METHODS BY UPLC-MS FOR THE METABOLOMIC STUDY OF TWO SPECIES OF EUCALYPTUS EXPOSED TO CHANGES IN TEMPERATURE AND CONCENTRATION OF CO2
• Grantee: João Benhur Mokochinski
• Support Opportunities: Scholarships in Brazil - Doctorate