Lessons from precision medicine in rheumatology

Author(s)

Muskardin, Theresa L. Wampler ; Paredes, Jacqueline L. ; Appenzeller, Simone ; Niewold, Timothy B.

• Document type: Journal article
• Source: MULTIPLE SCLEROSIS; v. 26, n. 5, p. 7-pg., 2020-01-22.

Abstract

Systemic lupus erythematosus (SLE) and rheumatoid arthritis (RA) are two common autoimmune rheumatic diseases that vary in severity, clinical presentation, and disease course between individuals. Molecular and genetic studies of both diseases have identified candidate genes and molecular pathways that are linked to various disease outcomes and treatment responses. Currently, patients can be grouped into molecular subsets in each disease, and these molecular categories should enable precision medicine approaches to be applied in rheumatic diseases. In this article, we will review key lessons learned about disease heterogeneity and molecular characterization in rheumatology, which we hope will lead to personalized therapeutic strategies. (AU)

• FAPESP's process: 08/02917-0 - Blood and cerebrospinal fluid biomarkers associated with structural and functional central nervous system abnormalities in systemic lupus erythematosus
• Grantee: Simone Appenzeller
• Support Opportunities: Research Grants - Young Investigators Grants
• FAPESP's process: 09/15286-1 - PREVALENCE AND FACTORS ASSOCIATED WITH THE METABOLIC SYNDROME IN YOUNG SYSTEMIC LUPUS ERYTEMATOSUS
• Grantee: Nailú Angélica Sinicato Martin
• Support Opportunities: Scholarships in Brazil - Scientific Initiation
• FAPESP's process: 19/06632-5 - Longitudinal evaluation of microstructural cerebral changes evaluated through MRI spectroscopy, pro-inflammatory cytokines and neuronal markers in systemic lupus erythematosus
• Grantee: Simone Appenzeller
• Support Opportunities: Regular Research Grants
• FAPESP's process: 13/07559-3 - BRAINN - The Brazilian Institute of Neuroscience and Neurotechnology
• Grantee: Fernando Cendes
• Support Opportunities: Research Grants - Research, Innovation and Dissemination Centers - RIDC
• FAPESP's process: 09/06049-6 - Blood and cerebrospinal fluid biomarkers associated with structural and functional central nervous system abnormalities in Systemic lupus erythematosus
• Grantee: Simone Appenzeller
• Support Opportunities: Scholarships in Brazil - Young Researchers