Autoantibodies targeting G protein-coupled receptors: An evolving history in autoimmunity. Report of the 4th international symposium

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Cabral-Marques, Otavio ; Moll, Guido ; Catar, Rusan ; Preuss, Beate ; Bankamp, Lukas ; Pecher, Ann-Christin ; Henes, Joerg ; Klein, Reinhild ; Kamalanathan, A. S. ; Akbarzadeh, Reza ; van Oostveen, Wieke ; Hohberger, Bettina ; Endres, Matthias ; Koolmoes, Bryan ; Levarht, Nivine ; Postma, Rudmer ; van Duinen, Vincent ; van Zonneveld, Anton Jan ; de Vries-Bouwstra, Jeska ; Fehres, Cynthia ; Tran, Florian ; Nery do Vale, Fernando Yuri ; da Silva Souza, Kamilla Batista ; Filgueiras, Igor Salerno ; Schimke, Lena F. ; Baiocchi, Gabriela Crispim ; de Miranda, Gustavo Cabral ; Mathias da Fonseca, Dennyson Leandro ; Freire, Paula Paccielli ; Hackel, Alexander M. ; Grasshoff, Hanna ; Stahle, Anja ; Mueller, Antje ; Dechend, Ralf ; Yu, Xinhua ; Petersen, Frank ; Sotzny, Franziska ; Sakmar, Thomas P. ; Ochs, Hans D. ; Schulze-Forster, Kai ; Heidecke, Harald ; Scheibenbogen, Carmen ; Shoenfeld, Yehuda ; Riemekasten, Gabriela

• Document type: Journal article
• Source: AUTOIMMUNITY REVIEWS; v. 22, n. 5, p. 14-pg., 2023-03-14.

Abstract

G protein-coupled receptors (GPCR) are involved in various physiological and pathophysiological processes. Functional autoantibodies targeting GPCRs have been associated with multiple disease manifestations in this context. Here we summarize and discuss the relevant findings and concepts presented in the biennial Interna-tional Meeting on autoantibodies targeting GPCRs (the 4th Symposium), held in Lubeck, Germany, 15-16 September 2022. The symposium focused on the current knowledge of these autoantibodies' role in various diseases, such as cardiovascular, renal, infectious (COVID-19), and autoimmune diseases (e.g., systemic sclerosis and systemic lupus erythematosus). Beyond their association with disease phenotypes, intense research related to the mechanistic action of these autoantibodies on immune regulation and pathogenesis has been developed, underscoring the role of autoantibodies targeting GPCRs on disease outcomes and etiopathogenesis. The observation repeatedly highlighted that autoantibodies targeting GPCRs could also be present in healthy in-dividuals, suggesting that anti-GPCR autoantibodies play a physiologic role in modeling the course of diseases. Since numerous therapies targeting GPCRs have been developed, including small molecules and monoclonal antibodies designed for treating cancer, infections, metabolic disorders, or inflammatory conditions, anti-GPCR autoantibodies themselves can serve as therapeutic targets to reduce patients' morbidity and mortality, repre-senting a new area for the development of novel therapeutic interventions. (AU)

• FAPESP's process: 18/18886-9 - Systemic and integrative analysis of the immune response to Zika and Dengue viral infections
• Grantee: Otávio Cabral Marques
• Support Opportunities: Research Grants - Young Investigators Grants
• FAPESP's process: 20/16246-2 - Holistic characterization of T cell exhaustion in patients with Zika
• Grantee: Dennyson Leandro Mathias da Fonseca
• Support Opportunities: Scholarships in Brazil - Doctorate (Direct)
• FAPESP's process: 20/01688-0 - Systemic and integrative analysis of the immune response to Zika and Dengue viral infections
• Grantee: Otávio Cabral Marques
• Support Opportunities: Scholarships in Brazil - Young Researchers
• FAPESP's process: 20/07069-0 - Systemic and integrative analysis of T lymphocyte exhaustion mechanisms in patients with COVID-19
• Grantee: Otávio Cabral Marques
• Support Opportunities: Regular Research Grants
• FAPESP's process: 20/07972-1 - Systemic and integrative analysis of T lymphocyte exhaustion mechanisms in patients with COVID-19
• Grantee: Gabriela Crispim Baiocchi
• Support Opportunities: Scholarships in Brazil - Doctorate (Direct)
• FAPESP's process: 20/05146-7 - Development of vaccine anti-SARS-CoV-2 based on VLPs
• Grantee: Gustavo Cabral de Miranda
• Support Opportunities: Regular Research Grants
• FAPESP's process: 19/14526-0 - Development of vaccines against Streptococcus pyogenes and Chikungunya Virus based on virus like particles
• Grantee: Gustavo Cabral de Miranda
• Support Opportunities: Research Grants - Young Investigators Grants