| Full text | |
| Author(s): |
Rodrigues, Bruna M.
;
Victoria, Henrique F. V.
;
Leite, Guilherme
;
Krambrock, Klaus
;
Chaves, Otavio A.
;
Oliveira, Diego F. de
;
Garcia, Rafael de Q.
;
De Boni, Leonardo
;
Costa, Luiz A. S.
;
Iglesias, Bernardo A.
Total Authors: 10
|
| Document type: | Journal article |
| Source: | Journal of Inorganic Biochemistry; v. 242, p. 16-pg., 2023-02-11. |
| Abstract | |
We report the synthesis and characterization of new tri-cationic corrole derivatives, containing Pt(II) or Pd(II) complexes attached at the peripheral position of thienyl moieties. Corrole derivatives were characterized through microanalysis, electrochemical, spectrometry and spectroscopy analysis. Singlet and triplet excited-states are investigated by photophysical/theoretical calculation methods and photobiological parameters were also eval-uated spectroscopic techniques (UV-Vis and EPR). Also, the binding capacity of each corrole derivative with nucleic acids (DNA) and human serum albumin (HSA) was determined by UV-Vis, steady-state, and time -resolved fluorescence spectroscopy, combined with molecular docking analysis. Moreover, the new corroles containing peripheral complexes improve their interactions with biomacromolecules, generate reactive oxygen species under light source irradiation studied and has potential for application in photodynamic therapeutic processes. (AU) | |
| FAPESP's process: | 20/16036-8 - Ultrafast spectroscopy: degenerated and non-degenerated pump-probe resolved in polarization |
| Grantee: | Rafael de Queiroz Garcia |
| Support Opportunities: | Scholarships in Brazil - Master |
| FAPESP's process: | 22/02439-9 - Ultrafast coherent spectroscopy in the sub-100 fs regime |
| Grantee: | Rafael de Queiroz Garcia |
| Support Opportunities: | Scholarships abroad - Research Internship - Master's degree |
| FAPESP's process: | 16/20886-1 - Ultrafast nonlinear optical spectroscopy: Transient Absorption and optical Kerr Gate with polarization control |
| Grantee: | Leonardo de Boni |
| Support Opportunities: | Regular Research Grants |
| FAPESP's process: | 18/11283-7 - Nonlinear Photonics: Spectroscopy and Advanced Processing of Materials |
| Grantee: | Cleber Renato Mendonça |
| Support Opportunities: | Research Projects - Thematic Grants |
| FAPESP's process: | 18/03758-5 - Assemblage of an Experimental Line of Laser Induced breakdown Spectroscopy (LIBS) with femtosecond pulses |
| Grantee: | Rafael de Queiroz Garcia |
| Support Opportunities: | Scholarships in Brazil - Scientific Initiation |
| FAPESP's process: | 21/07350-3 - Optical and time-resolved spectroscopic studies on new free based Corrol molecules |
| Grantee: | Diego França de Oliveira |
| Support Opportunities: | Scholarships in Brazil - Scientific Initiation |