Novel Gadolinium-Free Ultrasmall Nanostructured Positive Contrast for Magnetic Resonance Angiography and Imaging

Author(s)

Kawassaki, Rodrigo Ken ; Romano, Mariana ; Uchiyama, Mayara Klimuk ; Cardoso, Roberta Mansini ; Baptista, Mauriicio S. ; Farsky, Sandra H. P. ; Chaim, Khallil Taverna ; Guimaraes, Robson Raphael ; Araki, Koiti

• Document type: Journal article
• Source: Nano Letters; v. 23, n. 12, p. 9-pg., 2023-06-10.

Abstract

Nanostructured contrast agents are promising alternativesto Gd3+-based chelates in magnetic resonance (MR) imagingtechniques.A novel ultrasmall paramagnetic nanoparticle (UPN) was strategicallydesigned to maximize the number of exposed paramagnetic sites and r (1) while minimizing r (2), by decorating 3 nm titanium dioxide nanoparticles with suitableamounts of iron oxide. Its relaxometric parameters are comparableto those of gadoteric acid (GA) in agar phantoms, and the r (2)/r (1) ratio of 1.38at 3 T is close to the ideal unitary value. The strong and prolongedcontrast enhancement of UPN before renal excretion was confirmed by T (1)-weighted MR images of Wistar rats after intravenousbolus injection. Those results associated with good biocompatibilityindicate its high potential as an alternative blood-pool contrastagent to the GA gold standard for MR angiography, especially for patientswith severe renal impairment. (AU)

• FAPESP's process: 09/54323-0 - Imaging platform in the autopsy room
• Grantee: Paulo Hilário Nascimento Saldiva
• Support Opportunities: Multi-user Equipment Program
• FAPESP's process: 18/21489-1 - Supramolecular nanotechnology: design, materials and devices
• Grantee: Henrique Eisi Toma
• Support Opportunities: Research Projects - Thematic Grants
• FAPESP's process: 19/02151-2 - Development of MRI and PET/PECT dual mode theranostic nanoagent
• Grantee: Rodrigo Ken Kawassaki
• Support Opportunities: Scholarships in Brazil - Doctorate (Direct)