1,2-Arylsulfonylation of Vinyl Ethers and Esters Enabled by Dual Ni Catalysis

Author(s)

Pugnal, Lucas V. B. L. ; Vega, Kimberly B. ; Pissinati, Emanuele F. ; Correia, Jose Tiago M. ; Zukerman-Schpector, Julio ; Martin, Ruben ; Paixao, Marcio W.

• Document type: Journal article
• Source: CHEMCATCHEM; v. N/A, p. 6-pg., 2023-06-19.

Abstract

A dual photocatalytic sulfonylation-arylation of electron-rich alkenes is described. By combining sulfinate salts, (hetero)-aryl-bromides and 2,3-dihydrofuran under Ru and Ni dual catalysis, over 35 examples of aryl-sulfonylated scaffolds could be obtained in good to excellent yields, under mild reaction conditions and high diastereoselectivity. (AU)

• FAPESP's process: 21/06099-5 - Development of new photochemical methodologies for the synthesis of small molecule and biomolecule modifications
• Grantee: Márcio Weber Paixão
• Support Opportunities: Regular Research Grants
• FAPESP's process: 19/01560-6 - Nickel-catalyzed intermolecular dicarbofunctionalization of unactivated alkenes, employing CO2 and radical precursors
• Grantee: José Tiago Menezes Correia
• Support Opportunities: Scholarships abroad - Research Internship - Post-doctor
• FAPESP's process: 20/09353-7 - Tricomponent carbosulfonylation of enol-ethers and enamines via nickel/fotoredox dual catalysis
• Grantee: Lucas Valentin Bosi Loss Pugnal
• Support Opportunities: Scholarships in Brazil - Master
• FAPESP's process: 22/04597-0 - Synthesis of non-proteinogenic amino acids and modification of peptides using photocatalysis
• Grantee: Emanuele Ferrari Pissinati
• Support Opportunities: Scholarships in Brazil - Doctorate
• FAPESP's process: 17/10015-6 - Photocatalysis Applied to the Synthesis of N-heterocycles: New Strategies for Intercepting Radical Intermediates Generated in Processes Promoted by Visible-light-Tris (trimethylsilyl)silane Combination.
• Grantee: José Tiago Menezes Correia
• Support Opportunities: Scholarships in Brazil - Post-Doctoral
• FAPESP's process: 21/01354-7 - Photocatalysis applied to difunctionalization of alkenes via CO2 incorporation: multicomponent synthesis of ²-sulfonil and ±- (2-sulfenyl-indolyl) -carboxylic acids
• Grantee: Kimberly Benedetti Vega
• Support Opportunities: Scholarships in Brazil - Doctorate