| Full text | |
| Author(s): |
Higa, Guilherme Shigueto Vilar
;
Francis-Oliveira, Jose
;
Carlos-Lima, Estevao
;
Tamais, Alicia Moraes
;
Borges, Fernando da Silva
;
Kihara, Alexandre Hiroaki
;
Shieh, Iane Carvalho
;
Ulrich, Henning
;
Chiavegatto, Silvana
;
De Pasquale, Roberto
Total Authors: 10
|
| Document type: | Journal article |
| Source: | SCIENTIFIC REPORTS; v. 12, n. 1, p. 23-pg., 2022-12-05. |
| Abstract | |
Important functions of the prefrontal cortex (PFC) are established during early life, when neurons exhibit enhanced synaptic plasticity and synaptogenesis. This developmental stage drives the organization of cortical connectivity, responsible for establishing behavioral patterns. Serotonin (5-HT) emerges among the most significant factors that modulate brain activity during postnatal development. In the PFC, activated 5-HT receptors modify neuronal excitability and interact with intracellular signaling involved in synaptic modifications, thus suggesting that 5-HT might participate in early postnatal plasticity. To test this hypothesis, we employed intracellular electrophysiological recordings of PFC layer 5 neurons to study the modulatory effects of 5-HT on plasticity induced by theta-burst stimulation (TBS) in two postnatal periods of rats. Our results indicate that 5-HT is essential for TBS to result in synaptic changes during the third postnatal week, but not later. TBS coupled with 5-HT2A or 5-HT1A and 5-HT7 receptors stimulation leads to long-term depression (LTD). On the other hand, TBS and synergic activation of 5-HT1A, 5-HT2A, and 5-HT7 receptors lead to long-term potentiation (LTP). Finally, we also show that 5-HT dependent synaptic plasticity of the PFC is impaired in animals that are exposed to early-life chronic stress. (AU) | |
| FAPESP's process: | 19/21233-0 - Serotonergic modulation of spike timing dependent plasticity in the hippocampus |
| Grantee: | Alicia Moraes Tamais |
| Support Opportunities: | Scholarships in Brazil - Scientific Initiation |
| FAPESP's process: | 17/06100-8 - Susceptibility and resilience to the effects of chronic psychosocial stress in adolescence: participation of the neuronal nitric oxide synthase (nNOS) |
| Grantee: | Silvana Chiavegatto |
| Support Opportunities: | Regular Research Grants |
| FAPESP's process: | 16/09116-0 - Evaluation of TREK-1 physiological role in neural stress modulation |
| Grantee: | José Francis de Oliveira |
| Support Opportunities: | Scholarships in Brazil - Doctorate |
| FAPESP's process: | 22/00850-3 - Electrophysiological study of serotonergic modulation of the prefrontal cortex during postnatal development |
| Grantee: | Roberto De Pasquale |
| Support Opportunities: | Regular Research Grants |
| FAPESP's process: | 16/25840-0 - Serotonergic Modulation of Synaptic Plasticity in Post Natal Stress |
| Grantee: | Roberto De Pasquale |
| Support Opportunities: | Regular Research Grants |
| FAPESP's process: | 17/20253-1 - Modulation of 5HT1A Receptor in a Model of Stress |
| Grantee: | Iane Carvalho Shieh |
| Support Opportunities: | Scholarships in Brazil - Scientific Initiation |
| FAPESP's process: | 18/07366-4 - Purine and kinin receptors as targets of study and therapeutic interventions in neurological diseases |
| Grantee: | Alexander Henning Ulrich |
| Support Opportunities: | Research Projects - Thematic Grants |
| FAPESP's process: | 19/14962-5 - Serotoninergic modulation of spike timing dependent plasticity in cortical synapses |
| Grantee: | Roberto De Pasquale |
| Support Opportunities: | Regular Research Grants |