Dietary ?-Alanine Intake Assessed by Food Records Does Not Associate With Muscle Carnosine Content in Healthy, Active, Omnivorous Men and Women

Author(s)

Rezende, Nathalia Saffioti ; Bestetti, Giulia Cazetta ; de Oliveira, Luana Farias ; Mazzolani, Bruna Caruso ; Smaira, Fabiana Infante ; Dumas, Alina ; Swinton, Paul ; Saunders, Bryan ; Dolan, Eimear

• Document type: Journal article
• Source: INTERNATIONAL JOURNAL OF SPORT NUTRITION AND EXERCISE METABOLISM; v. N/A, p. 8-pg., 2023-03-24.

Abstract

beta-Alanine (BA) is one of the most widely used sport supplements, due to its capacity to improve high-intensity exercise performance by increasing muscle carnosine (MCarn) content, and consequently, the buffering capacity of the muscle. BA is also available in a variety of animal foods, but little is currently known about the influence of dietary BA intake on MCarn. The aim of the current study was to compile a detailed summary of available data on the BA content of commonly consumed foods, and to explore whether associations could be detected between self-reported dietary BA intake and skeletal MCarn in a group of 60 healthy, active, omnivorous men and women. Dietary BA intake was assessed via 3-day food records, and MCarn content assessed by high-performance liquid chromatography. A series of univariate and multivariate linear regression models were used to explore associations between estimated dietary BA and MCarn. No evidence of associations between dietary BA intake and MCarn were identified, with effect sizes close to zero calculated from models accounting for key demographic variables (f2 <= 0.02 for all analyses). These findings suggest that capacity to increase MCarn via dietary strategies may be limited, and that supplementation may be required to induce increases of the magnitude required to improve performance. (AU)

• FAPESP's process: 19/05616-6 - The bone response to exercise: a translational research program exploring clinical and mechanistic aspects
• Grantee: Eimear Bernadette Dolan
• Support Opportunities: Research Grants - Young Investigators Grants
• FAPESP's process: 21/06836-0 - Placebo in sports and exercise: prevalence, conditioning and open-placebo
• Grantee: Bryan Saunders
• Support Opportunities: Research Grants - Young Investigators Grants - Phase 2
• FAPESP's process: 22/09025-5 - Does acidosis moderate the bone metabolic response to acute exercise?
• Grantee: Nathália Saffioti Rezende
• Support Opportunities: Scholarships in Brazil - Master
• FAPESP's process: 19/26899-6 - The bone response to exercise a translational research program exploring clinical and mechanistic aspects
• Grantee: Eimear Bernadette Dolan
• Support Opportunities: Scholarships in Brazil - Young Researchers