Online Monitoring of Electrochemical Degradation of Paracetamol through a Biomimetic Sensor

Author(s)

Quintino de Oliveira, Mariana Calora ; de Vasconcelos Lanza, Marcos Roberto ; Paz Jara, Jose Luis ; Taboada Sotomayor, Maria Del Pilar

• Document type: Journal article
• Source: INTERNATIONAL JOURNAL OF ELECTROCHEMISTRY; v. 2011, p. 11-pg., 2011-01-01.

Abstract

This paper reports, for the first time, the online monitoring to the electrochemical degradation of the paracetamol using a biomimetic sensor coupled to a Flow Injection Analysis (FIA) system. The electrochemical degradation of the drug was carried out in aqueousmediumusing a flow-by reactor with a DSA anode. The process efficiency wasmonitored at real time by the biomimetic sensor constructed by modifying a glassy carbon electrode with a Nafion membrane doped with iron tetrapyridinoporphyrazine (FeTPyPz). Simultaneously, we carried out off-line analysis by liquid chromatography ( HPLC) during the experiments in order to validate the proposed system. In addition, to investigate the degradation products of the paracetamol electrolysis, we used the techniques of UPLC/MS and GC/MS. (AU)

• FAPESP's process: 08/00303-5 - Construction of biomimetic sensors for drugs determination and their coupling in flow systems
• Grantee: Maria Del Pilar Taboada Sotomayor
• Support Opportunities: Regular Research Grants
• FAPESP's process: 08/05899-3 - COUPLING OF A SENSOR AND AN ELECTROCHEMICAL REACTOR FOR ON LINE MONITORING OF THE ELECTROCHEMICAL DEGRADATION OF
• Grantee: Mariana Calora Quintino de Oliveira
• Support Opportunities: Scholarships in Brazil - Scientific Initiation