Metabolic Disturbance in PCOS: Clinical and Molecular Effects on Skeletal Muscle Tissue

Author(s)

Dantas, Wagner Silva ; Gualano, Bruno ; Rocha, Michele Patrocinio ; Grimaldi Barcellos, Cristiano Roberto ; Vieira Yance, Viviane dos Reis ; Miguel Marcondes, Jose Antonio

• Document type: Journal article
• Source: SCIENTIFIC WORLD JOURNAL; v. N/A, p. 7-pg., 2013-01-01.

Abstract

Polycystic ovary syndrome is a complex hormonal disorder affecting the reproductive and metabolic systems with signs and symptoms related to anovulation, infertility, menstrual irregularity and hirsutism. Skeletal muscle plays a vital role in the peripheral glucose uptake. Since PCOS is associated with defects in the activation and pancreatic dysfunction of beta-cell insulin, it is important to understand the molecular mechanisms of insulin resistance in PCOS. Studies of muscle tissue in patients with PCOS reveal defects in insulin signaling. Muscle biopsies performed during euglycemic hyperinsulinemic clamp showed a significant reduction in glucose uptake, and insulin-mediated IRS-2 increased significantly in skeletal muscle. It is recognized that the etiology of insulin resistance in PCOS is likely to be as complicated as in type 2 diabetes and it has an important role in metabolic and reproductive phenotypes of this syndrome. Thus, further evidence regarding the effect of nonpharmacological approaches (e.g., physical exercise) in skeletal muscle of women with PCOS is required for a better therapeutic approach in the management of various metabolic and reproductive problems caused by this syndrome. (AU)

• FAPESP's process: 12/02827-7 - Acute effects of exercise training on molecular pathways of glucose uptake in skeletal muscle in patients with Polycystic Ovary Syndrome
• Grantee: Wagner Silva Dantas
• Support Opportunities: Scholarships in Brazil - Master
• FAPESP's process: 12/14650-4 - Acute effect of exercise on molecular pathways related to skeletal muscle glucose uptake in patients with polycystic ovary syndrome
• Grantee: Bruno Gualano
• Support Opportunities: Regular Research Grants