Exercise training in hypertension: Role of microRNAs

Author(s)

das Neves, Vander Jose ; Fernandes, Tiago ; Roque, Fernanda Roberta ; Reno Soci, Ursula Paula ; Soares Melo, Stephano Freitas ; de Oliveira, Edilamar Menezes

• Document type: Journal article
• Source: WORLD JOURNAL OF CARDIOLOGY; v. 6, n. 8, p. 15-pg., 2014-08-26.

Abstract

Hypertension is a complex disease that constitutes an important public health problem and demands many studies in order to understand the molecular mechanisms involving his pathophysiology. Therefore, an increasing number of studies have been conducted and new therapies are continually being discovered. In this context, exercise training has emerged as an important non-pharmacological therapy to treat hypertensive patients, minimizing the side effects of pharmacological therapies and frequently contributing to allow pharmacotherapy to be suspended. Several mechanisms have been associated with the pathogenesis of hypertension, such as hyperactivity of the sympathetic nervous system and renin-angiotensin aldosterone system, impaired endothelial nitric oxide production, increased oxygen-reactive species, vascular thickening and stiffening, cardiac hypertrophy, impaired angiogenesis, and sometimes genetic predisposition. With the advent of microRNAs (miRNAs), new insights have been added to the perspectives for the treatment of this disease, and exercise training has been shown to be able to modulate the miRNAs associated with it. Elucidation of the relationship between exercise training and miRNAs in the pathogenesis of hypertension is fundamental in order to understand how exercise modulates the cardiovascular system at genetic level. This can be promising even for the development of new drugs. This article is a review of how exercise training acts on hypertension by means of specific miRNAs in the heart, vascular system, and skeletal muscle. (C) 2014 Baishideng Publishing Group Inc. All rights reserved. (AU)

• FAPESP's process: 10/50048-1 - Cellular and functional bases of exercise in cardiovascular diseases
• Grantee: Carlos Eduardo Negrão
• Support Opportunities: Research Projects - Thematic Grants
• FAPESP's process: 13/10472-7 - Swimming exercise training in vascular remodeling of coronary arteries of spontaneously hypertensive rats: effects on the expression of microRNAs and perspective of identifying therapeutic targets.
• Grantee: Fernanda Roberta Roque Redondo
• Support Opportunities: Scholarships in Brazil - Post-Doctoral
• FAPESP's process: 10/09438-0 - THERAPEUTIC USE OF microRNA RESPONSIBLE FOR REGULATING CARDIAC CONTRACTILITY ASSOCIATED WITH EXERCISE TRAINING AEROBIC IN RATS WITH HEART FAILURE
• Grantee: Stéphano Freitas Soares Melo
• Support Opportunities: Scholarships in Brazil - Doctorate
• FAPESP's process: 12/04104-2 - MicroRNAs expression in the thoracic aorta of normotensive rats submitted to physical training: perspectives for identifying therapeutic targets related to hypertension.
• Grantee: Vander José das Neves
• Support Opportunities: Scholarships in Brazil - Post-Doctoral