An Electrochemical Sensor for the Simultaneous Determination of Paracetamol and Codeine Using a Glassy Carbon Electrode Modified with Nickel Oxide Nanoparticles and Carbon Black

Author(s)

Deroco, Patricia Batista ; Vicentini, Fernando Campanha ; Fatibello-Filho, Orlando

• Document type: Journal article
• Source: Electroanalysis; v. 27, n. 9, p. 7-pg., 2015-09-01.

Abstract

In this work, a simple and highly selective voltammetric method was developed for the simultaneous determination of paracetamol (PCT) and codeine (COD) in pharmaceuticals and human body fluids employing a glassy carbon electrode modified with carbon black (CB) and nickel oxide nanoparticles (NiONPs) within a dihexadecylphosphate (DHP) film. Using square-wave voltammetry (SWV), a separation of ca. 550 mV between the oxidation peak potentials of PCT and COD was obtained. The simultaneous determination of PCT and COD presented a linear concentration range from 3.0 to 47.8 mu mol L-1 for PCT and from 0.83 to 38.3 mu mol L-1 for COD. (AU)

• FAPESP's process: 13/16770-0 - SENSORS DEVELOPMENT BASED ON POLYMERIC FILMS AND NANOMATERIALS FOR SEVERAL ANALYTICAL APPLICATIONS
• Grantee: Fernando Campanhã Vicentini
• Support Opportunities: Scholarships in Brazil - Post-Doctoral
• FAPESP's process: 14/07919-2 - Preparation of electrodes with new carbon-based materials for applications in electroanalytical
• Grantee: Patrícia Batista Deroco
• Support Opportunities: Scholarships in Brazil - Doctorate