| Full text | |
| Author(s): |
Correa, Michelle Fidelis
;
Ramos Barbosa, Alefe Jhonatas
;
Sato, Rie
;
Junqueira, Luis Otavio
;
Politi, Mario Jose
;
Rando, Daniela Goncales
;
dos Santos Fernandes, Joao Paulo
Total Authors: 7
|
| Document type: | Journal article |
| Source: | GREEN PROCESSING AND SYNTHESIS; v. 5, n. 2, p. 7-pg., 2016-04-01. |
| Abstract | |
Iodocyclization of 2-allylphenols is a suitable method to access furans and dihydrofurans with adequate yields. Several methodologies to iodocyclization are reported in the literature; however, since some data about the conditions are conflicting, a more systematic approach is needed to define the best conditions. In this work, we performed a full 22 factorial design to study the influence of solvent (water or EtOH: water (1: 9) mixture) and the addition of NaHCO3 in iodine-promoted cyclization of 2-allylphenols. The results have shown water as the best solvent to be employed in the cyclization of liquid 2-allylphenols, and the presence of NaHCO 3 leads to lower yields. Several examples of 2-iodomethyl-2,3-dihydrobenzofurans preparations are reported using the optimized conditions; however, high yields are only observed when liquid 2-allylphenols were used. (AU) | |
| FAPESP's process: | 13/20479-9 - Synthesis and evaluation of compounds potentially ligands of H4 receptors |
| Grantee: | João Paulo dos Santos Fernandes |
| Support Opportunities: | Regular Research Grants |
| FAPESP's process: | 13/01875-0 - Parallel synthesis, in vitro screening and SAR studies of a nitroderivatives compounds library active against macrophage's pathogens: Mycobacterium tuberculosis NRP forms and Leishmania sp |
| Grantee: | Daniela Goncales Galasse Rando |
| Support Opportunities: | Regular Research Grants |