BDNF trafficking and signaling impairment during early neurodegeneration is prevented by moderate physical activity

Author(s)

Almeida, Michael F. ; Chaves, Rodrigo S. ; Silva, Carolliny M. ; Chaves, Juliana C. S. ; Melo, Karla P. ; Ferrari, Merari F. R.

• Document type: Journal article
• Source: IBRO REPORTS; v. 1, p. 13-pg., 2016-12-01.

Abstract

Physical exercise can attenuate the effects of aging on the central nervous system by increasing the expression of neurotrophins such as brain-derived neurotrophic factor (BDNF), which promotes dendritic branching and enhances synaptic machinery, through interaction with its receptor TrkB. TrkB receptors are synthesized in the cell body and are transported to the axonal terminals and anchored to plasma membrane, through SLP1, CRMP2 and Rab27B, associated with KIF1B. Retrograde trafficking is made by EDH-4 together with dynactin and dynein molecular motors. In the present study it was found that early neurodegeneration is accompanied by decrease in BDNF signaling, in the absence of hyperphosphorylated tau aggregation, in hippocampus of 11 months old Lewis rats exposed to rotenone. It was also demonstrated that moderate physical activity (treadmill running, during 6 weeks, concomitant to rotenone exposure) prevents the impairment of BDNF system in aged rats, which may contribute to delay neurodegeneration. In conclusion, decrease in BDNF and TrkB vesicles occurs before large aggregate-like p-Tau are formed and physical activity applied during early neurodegeneration may be of relevance to prevent BDNF system decay. (C) 2016 The Authors. Published by Elsevier Ltd on behalf of International Brain Research Organization. (AU)

• FAPESP's process: 11/15281-0 - Effects of moderate physical exercise upon intracellular trafficking of neurotrophins and their receptors in the central nervous system of aged rats
• Grantee: Michael Fernandes de Almeida
• Support Opportunities: Scholarships in Brazil - Master
• FAPESP's process: 11/00478-2 - Influence of calcium and MIRO proteins on mitochondrial mobility before and during protein aggregation involved in neurodegeneration
• Grantee: Rodrigo dos Santos Chaves
• Support Opportunities: Scholarships in Brazil - Doctorate (Direct)
• FAPESP's process: 12/15495-2 - Mitochondria trafficking and autophagy in human dopaminergic neurons derived from embryonic and induced-pluripotent stem cells
• Grantee: Merari de Fátima Ramires Ferrari
• Support Opportunities: Regular Research Grants
• FAPESP's process: 11/15283-2 - Autophagocytosis and oxidative stress in the central nervous system of aged rats submitted to moderate physical exercise
• Grantee: Carolliny Moura da Silva
• Support Opportunities: Scholarships in Brazil - Master
• FAPESP's process: 13/08028-1 - CEGH-CEL - Human Genome and Stem Cell Research Center
• Grantee: Mayana Zatz
• Support Opportunities: Research Grants - Research, Innovation and Dissemination Centers - RIDC