Stationary RNA polymerase fluctuations during transcription elongation

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Author(s):	Belitsky, V ; Schuetz, G. M. Total Authors: 2
Document type:	Journal article
Source:	PHYSICAL REVIEW E; v. 99, n. 1, p. 10-pg., 2019-01-07.
Abstract
We study fluctuation effects of nonsteric molecular interactions between RNA polymerase (RNAP) motors that move simultaneously on the same DNA track during transcription elongation. Based on a stochastic model that allows for the exact analytical computation of the stationary distribution of RNAPs as a function of their density, interaction strength, nucleoside triphosphate concentration, and rate of pyrophosphate release we predict an almost geometric headway distribution of subsequent RNAP transcribing on the same DNA segment. The localization length which characterizes the decay of the headway distribution depends directly only the average density of RNAP and the interaction strength, but not on specific single-RNAP properties. Density correlations are predicted to decay exponentially with the distance (in units of DNA base pairs), with a correlation length that is significantly shorter than the localization length. (AU)

FAPESP's process:	17/20696-0 - From interacting particle systems to topological data analysis
Grantee:	Vladimir Belitsky
Support Opportunities:	Research Grants - Visiting Researcher Grant - International


FAPESP's process:	17/10555-0 - Stochastic modeling of interacting systems
Grantee:	Fabio Prates Machado
Support Opportunities:	Research Projects - Thematic Grants