Application of the Principles of Green Chemistry for the Development of a New and Sensitive Method for Analysis of Ertapenem Sodium by Capillary Electrophoresis

Author(s)

Pedroso, Tahisa Marcela ; Van Schepdael, Ann ; Nunes Salgado, Herida Regina

• Document type: Journal article
• Source: INTERNATIONAL JOURNAL OF ANALYTICAL CHEMISTRY; v. 2019, p. 11-pg., 2019-01-01.

Abstract

An innovative method is validated for the analysis of ertapenem sodium by capillary electrophoresis using potassium phosphate buffer 10mM pH 7 and 15kV voltage, in the concentration range of 70 to 120gmL(-1). Ertapenem had a migration time of 3.15 minutes and the linearity curve was y = 2281.7 x - 24495 with a R-2 = 0.9994. Thus, we propose a routine analysis method that meets the principles of green analytical chemistry for the routine analysis of ertapenem sodium by capillary electrophoresis. (AU)

• FAPESP's process: 09/14825-6 - PHARMACEUTICAL ANALISIS OF DRUGS AND MEDICINES: CEFUROXIME, TEICOPLANIN AND AZUMOLENE
• Grantee: Hérida Regina Nunes Salgado
• Support Opportunities: Regular Research Grants
• FAPESP's process: 13/12959-0 - DEVELOPMENT AND VALIDATION OF ANALYTICAL METHODS FOR CHARACTERIZATION AND QUANTIFICATION OF ERTAPENEM SODIUM IN LYOPHILIZED POWDER FOR INJECTABLE SOLUTION
• Grantee: Tahisa Marcela Pedroso
• Support Opportunities: Scholarships in Brazil - Doctorate