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Development of an automated solid-phase microextraction based on an arrangement with microsyringes packed sorbent for the simultaneous preparation of multiple samples

Grant number: 14/03765-0
Support type:Scholarships in Brazil - Doctorate
Effective date (Start): December 01, 2014
Effective date (End): October 31, 2018
Field of knowledge:Physical Sciences and Mathematics - Chemistry - Analytical Chemistry
Cooperation agreement: Coordination of Improvement of Higher Education Personnel (CAPES)
Principal researcher:Fernando Mauro Lanças
Grantee:Deyber Arley Vargas Medina
Home Institution: Instituto de Química de São Carlos (IQSC). Universidade de São Paulo (USP). São Carlos , SP, Brazil
Associated scholarship(s):16/21950-5 - Automation strategies for miniaturized sample preparation, Case: Automated online in syringe stirred SDME,, BE.EP.DR


The microextraction by packed sorbent (MEPS) has excelled in recent years as a versatile and cost effective technique for sample preparation presenting compatibility with the principles of green analytical chemistry; therefore permitting the handling of small sample volumes with high efficiency in the recovery of analytes. Most applications involve the use of MEPS technique either manually or at line coupled to chromatographic systems using automatic injectors (autosampler), which prepare the samples individually and sequentially. These systems present high cost and yet there are no national arrangements for this purpose. This research proposal aims to develop a prototype system to prepare samples offline, based on MEPS. It will allow the simultaneous preparation of a set of samples in an automated, rapid, inexpensive and highly reproducible way. Additionally, taking into account that the miniaturization of liquid chromatography has allowed considerable increase in the sensitivity of the analytical methods and that the association of miniaturized sample preparation, such as MEPS, with miniaturized chromatographic methods have not been widely explored, a second component of the project seeks to link the sample preparation through automated off-line MEPS with online pre-concentration by capillary liquid chromatography (cLC). (AU)

News published in Agência FAPESP Newsletter about the scholarship:

Scientific publications (4)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
MACIEL, EDVALDO VASCONCELOS SOARES; MEDINA, DEYBER ARLEY VARGAS; BORSATTO, JOAO VICTOR BASSOLLI; LANCAS, FERNANDO MAURO. Towards a universal automated and miniaturized sample preparation approach. SUSTAINABLE CHEMISTRY AND PHARMACY, v. 21, JUN 2021. Web of Science Citations: 0.
VARGAS MEDINA, DEYBER ARLEY; PEREIRA DOS SANTOS, NATALIA GABRIELLY; DA SILVA BURATO, JULIANA SOARES; BASOLLI BORSATTO, JOAO VICTOR; LANCAS, FERNANDO MAURO. An overview of open tubular liquid chromatography with a focus on the coupling with mass spectrometry for the analysis of small molecules. Journal of Chromatography A, v. 1641, MAR 29 2021. Web of Science Citations: 0.
DA SILVA, LUIS FELIPE; VARGAS MEDINA, DEYBER ARLEY; LANCAS, FERNANDO MAURO. Automated needle-sleeve based online hyphenation of solid-phase microextraction and liquid chromatography. Talanta, v. 221, JAN 1 2021. Web of Science Citations: 0.
VARGAS MEDINA, DEYBER ARLEY; SOARES MACIEL, EDVALDO VASCONCELOS; LANCAS, FERNANDO MAURO. Miniaturization of liquid chromatography coupled to mass spectrometry. 3. Achievements on chip-based LC-MS devices. TRAC-TRENDS IN ANALYTICAL CHEMISTRY, v. 131, OCT 2020. Web of Science Citations: 0.
Academic Publications
(References retrieved automatically from State of São Paulo Research Institutions)
MEDINA, Deyber Arley Vargas. Open-Source robotics in the automation of sample preparation for the chromatographic analysis of organic compounds. 2018. Doctoral Thesis - Universidade de São Paulo (USP). Instituto de Química de São Carlos São Carlos.

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Filed patent(s) as a result of this research project

Solicitação em análise e dentro do prazo legal de sigilo previsto na legislação BR1020180093304 - Universidade de São Paulo (USP) . Solicitação em análise e dentro do prazo legal de sigilo previsto na legislação - May 2018, 08