|Support type:||Scholarships in Brazil - Doctorate|
|Effective date (Start):||October 01, 2013|
|Effective date (End):||September 30, 2016|
|Field of knowledge:||Physical Sciences and Mathematics - Chemistry - Analytical Chemistry|
|Principal researcher:||Alvaro José dos Santos Neto|
|Grantee:||Scarlet Nere Ortega|
|Home Institution:||Instituto de Química de São Carlos (IQSC). Universidade de São Paulo (USP). São Carlos , SP, Brazil|
The occurrence of pharmaceutical products in the aquatic environment has increased the concern over the potential impact to the aquatic biota. In particular broad activity spectrum antibiotics, as fluoroquinolones (FQ), which possibly contribute to proliferation of antibiotic resistant bacteria. Due to the concern to the presence, persistence and fate of these products in environment, it has increased the development of very sensitive analytical methods suitable for the monitoring of antibiotics in trace levels. Many procedures published in the existing literature for analysis of FQs in environmental samples use bidimensional chromatography, column switching, in conventional scale. Besides, not much attention has been paid to MIP and RAM-MIP materials for fully automated and miniaturized configuration of SPE coupled to capillary liquid chromatography (cLC). Therefore, this work aims the development and evaluation of capillary columns packed with RAM-MIP sorbent for analysis of complex matrix containing fluoroquinolones, by SPE column switching coupled to cLC. This miniaturized approach will minimize time and analyses expenses and can contribute for the field development.