Current evidence on cognitive improvement and neuroprotection promoted by anthocyanins

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Author(s):	dos Santos, Nathalia Medina ; Batista, Patricia Berilli ; Batista, Angela Giovana ; Marostica Junior, Mario Roberto Total Authors: 4
Document type:	Journal article
Source:	CURRENT OPINION IN FOOD SCIENCE; v. 26, p. 8-pg., 2019-04-01.
Abstract
In this review, we focus on presenting the results of the last few years and pioneer publications that link the administration of anthocyanin-rich products and improved cognitive function. In vitro studies proposed modulation of oxidative stress, inflammation, and degeneration in neurons as main mechanisms by which anthocyanins could improve cognition. In vivo studies showed also regulation of synaptic plasticity, clearance of intra and extracellular toxical proteins and improvement of learning and memory tasks after administration of anthocyanin-rich products. The ingestion of berries and other anthocyanin-rich products in clinical trials demonstrated potential to delay age-related neurodegeneration, suppress neuroinflammation, improve vascular function and consequently enhance cognitive functions. Anthocyanins-rich foods are promising neuroprotectors preventing cognitive impairment of aging and neurodegenerative diseases. (AU)

FAPESP's process:	15/50333-1 - COBRA: a novel compound discovery pipeline for rapid and cost-effective identification of bioactives with health beneficial effects in Brazilian crops
Grantee:	Glaucia Maria Pastore
Support Opportunities:	Research Projects - Thematic Grants