Meliponamycins: Antimicrobials from Stingless Bee-Associated Streptomyces sp.

Author(s)

Menegatti, Carla ; Lourenzon, Vitor Bruno ; Rodriguez-Hernandez, Diego ; da Paixao Melo, Weilan Gomes ; Gomes Ferreira, Leonardo Luiz ; Andricopulo, Adriano Defini ; do Nascimento, Fabio Santos ; Pupo, Monica Tallarico

• Document type: Journal article
• Source: Journal of Natural Products; v. 83, n. 3, p. 7-pg., 2020-03-27.

Abstract

Social insects establish complex interactions with microorganisms, some of which play defensive roles in colony protection. The important role of pollinators such as the stingless bee Melipona scutellaris in nature encouraged us to pursue efforts to study its associated microbiota. Here we describe the discovery of two novel cyclic hexadepsipeptides, meliponamycin A (1) and meliponamycin B (2), from Streptomyces sp. ICBG1318 isolated from M. scutellaris nurse bees. Their structures were established by interpretation of NMR and MS data, and the absolute configuration of the constituent amino acids was determined by the advanced Marfey's method. Compounds 1 and 2 showed strong activity against the entomopathogen Paenibacillus larvae and human pathogens Staphylococcus aureus and Leishmania infantum. (AU)

• FAPESP's process: 18/07153-0 - Application of OSMAC and co-culture approaches to diversify the secondary metabolism of Streptomyces albiaxialis ICBG1318
• Grantee: Vitor Bruno Lourenzon
• Support Opportunities: Scholarships in Brazil - Scientific Initiation
• FAPESP's process: 13/07600-3 - CIBFar - Center for Innovation in Biodiversity and Drug Discovery
• Grantee: Glaucius Oliva
• Support Opportunities: Research Grants - Research, Innovation and Dissemination Centers - RIDC
• FAPESP's process: 13/50954-0 - Novel therapeutic agents from the bacterial symbionts of Brazilian invertebrates
• Grantee: Mônica Tallarico Pupo
• Support Opportunities: BIOTA-FAPESP Program - Thematic Grants
• FAPESP's process: 16/15576-3 - Natural products involved in symbiosis between actinobacteria and social insects
• Grantee: Carla Menegatti
• Support Opportunities: Scholarships in Brazil - Doctorate
• FAPESP's process: 15/01001-6 - Discovering bacterial symbionts diversity associated with ants in different Brazilian biomes
• Grantee: Weilan Gomes da Paixão Melo
• Support Opportunities: Scholarships in Brazil - Post-Doctoral
• FAPESP's process: 14/17620-4 - Bacterial symbionts associated with stingless bee Melipona scutellaris as sources of bioactive natural products
• Grantee: Carla Menegatti
• Support Opportunities: Scholarships in Brazil - Master
• FAPESP's process: 17/01188-4 - Relationship of the protozoan Crithidia spp with bacterioma associated with the stingless bee Melipona scutellaris: chemical, ecological and pharmacological studies
• Grantee: Diego Carlos Rodriguez Hernandez
• Support Opportunities: Scholarships in Brazil - Post-Doctoral