| Grant number: | 17/01188-4 |
| Support Opportunities: | Scholarships in Brazil - Post-Doctoral |
| Start date: | June 01, 2017 |
| End date: | May 31, 2019 |
| Field of knowledge: | Physical Sciences and Mathematics - Chemistry - Organic Chemistry |
| Agreement: | Coordination of Improvement of Higher Education Personnel (CAPES) |
| Principal Investigator: | Mônica Tallarico Pupo |
| Grantee: | Diego Carlos Rodriguez Hernandez |
| Host Institution: | Faculdade de Ciências Farmacêuticas de Ribeirão Preto (FCFRP). Universidade de São Paulo (USP). Ribeirão Preto , SP, Brazil |
Abstract In recent decades, symbiotic microorganisms have demonstrated the ability to biosynthesize compounds with high biological potential, generating high attention in research in several areas. It is known that social insects are exposed to various abiotic and biotic environmental pressures by increasing of their susceptibility against natural enemies such as pathogens. Thus, these insects evolutionarily developed mechanisms of defenses associating with bacteria that act like bodyguard of the host against these enemies. In this context, within the scope of the ICBG project "Novel therapeutic agents from the bacterial symbionts of Brazilian invertebrates", this project aims to prioritize the study of the bacterioma associated with the stingless bees Melipona scutellaris and to verify if there is any interspecific relationship of protection mediated by secondary microbial metabolites against the protozoan Crithidia spp., which is associated with disease that leads to the collapse of bees colonies (CCD) and against other entomopathogenic microorganisms such as Beauveria bassiana, Metarhizium anisopliae and Paenibacillus larvae (Chemical Ecology). The use of chromatographic methods will allow to monitor, identify and isolate microbial secondary metabolites of interest, to be characterized with the extensive use of spectroscopic, spectrometric and other methods that are necessary (Chemistry of Natural Products). The knowledge of the protective ecological function of the characterized natural products may contribute more rationally to the discovery of compounds with antiprotozoal potential (Medicinal Chemistry), aligning ecological function to possible therapeutic function. | |
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