Cholesteryl Ester Transfer Protein and Lipid Metabolism and Cardiovascular Diseases

Author(s)

Oliveira, Helena C. F. ; Raposo, Helena F. ; Jiang, XC

• Document type: Journal article
• Source: LIPID TRANSFER IN LIPOPROTEIN METABOLISM AND CARDIOVASCULAR DISEASE; v. 1276, p. 11-pg., 2020-01-01.

Abstract

In this chapter, we present the major advances in CETP research since the detection, isolation, and characterization of its activity in the plasma of humans and several species. Since CETP is a major modulator of HDL plasma levels, the clinical importance of CETP activity was recognized very early. We describe the participation of CETP in reverse cholesterol transport, conflicting results in animal and human genetic studies, possible new functions of CETP, and the results of the main clinical trials on CETP inhibition. Despite major setbacks in clinical trials, the hypothesis that CETP inhibitors are anti-atherogenic in humans is still being tested. (AU)

• FAPESP's process: 13/07607-8 - OCRC - Obesity and Comorbidities Research Center
• Grantee: Licio Augusto Velloso
• Support Opportunities: Research Grants - Research, Innovation and Dissemination Centers - RIDC
• FAPESP's process: 17/17728-8 - Mitochondrial function and dysfunction: implications for aging and associated diseases
• Grantee: Aníbal Eugênio Vercesi
• Support Opportunities: Research Projects - Thematic Grants
• FAPESP's process: 15/17555-0 - Impact of CETP expression on brown and beige adipose tissues and its contribution to the obesity control.
• Grantee: Helena Fonseca Raposo
• Support Opportunities: Scholarships in Brazil - Post-Doctoral