| Full text | |
| Author(s): |
Peracoli, Maria T. S.
[1]
;
Bannwart, Camila F.
[2]
;
Cristofalo, Renata
[1]
;
Medeiros Borges, Vera T.
[2]
;
Araujo Costa, Roberto A.
[2]
;
Witkin, Steven S.
[3]
;
Peracoli, Jose C.
[2]
Total Authors: 7
|
| Affiliation: | [1] UNESP Sao Paulo State Univ, Dept Microbiol & Immunol, Inst Biociences, Sao Paulo - Brazil
[2] UNESP Sao Paulo State Univ, Dept Obstet & Ginecol, Botucatu Med Sch, Sao Paulo - Brazil
[3] Cornell Univ, Div Immunol & Infect Dis, Weill Med Coll, Dept Obstet & Gynecol, New York, NY 10021 - USA
Total Affiliations: 3
|
| Document type: | Journal article |
| Source: | American Journal of Reproductive Immunology; v. 66, n. 6, p. 460-467, DEC 2011. |
| Web of Science Citations: | 28 |
| Abstract | |
Problem To evaluate associations between hyperuricemia and increases in production of reactive oxygen species (ROS) and tumor necrosis factor alpha (TNF-alpha) in pre-eclamptic pregnancies. Method of study This study investigated serum uric acid levels, monocyte production of TNF-alpha, superoxide anion (O(2)(-)) and hydrogen peroxide (H(2)O(2)), as well as superoxide dismutase (SOD) and catalase (CAT) activities in erythrocytes from 30 women with pre-eclampsia (PE) compared with 30 normotensive (NT) pregnant women in the last trimester of pregnancy. Results Serum uric acid levels (6.1 versus 2.8 mg/dL) as well as endogenous O(2)(-) (2.2 versus 1.6 nm), H(2)O(2) (1.8 versus 1.4 nm) and TNF-alpha (91.6 versus 40.4 pg/mL) released from monocytes were significantly higher in the pre-eclamptic group than in the NT group (P < 0.05). SOD activity in erythrocytes was also significantly elevated in the PE group (5969.2 versus 4834.7 U/g Hb). No significant difference between groups was observed in relation to CAT activity. Conclusions Elevated serum uric acid levels are correlated with higher O(2)(-) and TNF-alpha production by monocytes in women with PE. This may contribute to the enhanced oxidative and inflammatory state characteristic of this disorder. (AU) | |
| FAPESP's process: | 06/07095-3 - Efeito modulador da silimarina (Silybum marianum) no mecanismo fisiopatológico da pré-eclâmpsia |
| Grantee: | Jose Carlos Peraçoli |
| Support Opportunities: | Regular Research Grants |