| Full text | |
| Author(s): |
Correia, Lucas Antonio Arias
;
Garcia, Rodrigo Santos
;
Real, Caroline Cristiano
;
Uzueli, Daniel Henrique
;
Sa, Ulisses Lacerda de Figueiredo
;
Marques, Fabio Luiz Navarro
;
Colnago, Luiz Alberto
;
Esposito, Breno Pannia
Total Authors: 8
|
| Document type: | Journal article |
| Source: | CHEMICAL PAPERS; v. 75, n. 3, p. 7-pg., 2020-09-30. |
| Abstract | |
The linker p-SCN-Bz-desferrioxamine was used as a conjugating agent to bovine serum albumin. The conjugate (BSA-DFO) did not display relevant structural alterations in comparison with the native protein. BSA-DFO was able to bind iron in a high affinity, antioxidant form similar to the native siderophore desferrioxamine. The gadolinium complex of BSA-DFO displayed 7-10 times higher relaxivities compared to the low molecular weight complex. Preparation of the radiotracers(68)Ga(BSA-DFO) and(89)Zr(BSA-DFO) in high radiochemical yields was accomplished quickly in mild conditions. These results indicate that BSA-DFO might be useful as an alternative treatment for iron overload disorders, and as a platform for the production of radiotracers or contrast agents for magnetic resonance imaging. (AU) | |
| FAPESP's process: | 16/03709-9 - Modulation of the levels and reactivity of physiological iron by mean of new natural or bifunctional chelators: possible applications in human health |
| Grantee: | Breno Pannia Esposito |
| Support Opportunities: | Regular Research Grants |
| FAPESP's process: | 17/16379-0 - Desferriosamine: albumin conjugates for the therapy of iron overload |
| Grantee: | Lucas Antonio Arias Correia |
| Support Opportunities: | Scholarships in Brazil - Scientific Initiation |