Real-Time Monitoring of Neurocritical Patients with Diffuse Optical Spectroscopies

Author(s)

Forti, Rodrigo Menezes ; Katsurayama, Marilise ; Valler, Lenise ; Quiroga, Andres ; Simioni, Luiz ; Menko, Julien ; Falcao, Antonio L. E. ; Li, Li Min ; Mesquita, Rickson C.

• Document type: Journal article
• Source: JOVE-JOURNAL OF VISUALIZED EXPERIMENTS; v. N/A, n. 165, p. 20-pg., 2020-11-01.

Abstract

Neurophysiological monitoring is an important goal in the treatment of neurocritical patients, as it may prevent secondary damage and directly impact morbidity and mortality rates. However, there is currently a lack of suitable non-invasive, real-time technologies for continuous monitoring of cerebral physiology at the bedside. Diffuse optical techniques have been proposed as a potential tool for bedside measurements of cerebral blood flow and cerebral oxygenation in case of neurocritical patients. Diffuse optical spectroscopies have been previously explored to monitor patients in several clinical scenarios ranging from neonatal monitoring to cerebrovascular interventions in adults. However, the feasibility of the technique to aid clinicians by providing real-time information at the bedside remains largely unaddressed. Here, we report the translation of a diffuse optical system for continuous real-time monitoring of cerebral blood flow, cerebral oxygenation, and cerebral oxygen metabolism during intensive care. The real-time feature of the instrument could enable treatment strategies based on patient-specific cerebral physiology rather than relying on surrogate metrics, such as arterial blood pressure. By providing real-time information on the cerebral circulation at different time scales with relatively cheap and portable instrumentation, this approach may be especially useful in low-budget hospitals, in remote areas and for monitoring in open fields (e.g., defense and sports). (AU)

• FAPESP's process: 14/25486-6 - Construction and evaluation of a frequency-domain diffuse optical spectroscopy device for brain monitoring in the clinic
• Grantee: Rodrigo Menezes Forti
• Support Opportunities: Scholarships in Brazil - Doctorate
• FAPESP's process: 12/02500-8 - Instrumentation and methodology development for cerebral oxygenation, blood flow and metabolic monitoring with diffuse optical spectroscopies
• Grantee: Rickson Coelho Mesquita
• Support Opportunities: Research Grants - Young Investigators Grants
• FAPESP's process: 13/07559-3 - BRAINN - The Brazilian Institute of Neuroscience and Neurotechnology
• Grantee: Fernando Cendes
• Support Opportunities: Research Grants - Research, Innovation and Dissemination Centers - RIDC