| Full text | |
| Author(s): |
Vinicius Alves Lima
;
Renata Elen Costa Silva
;
Luiz Henrique Moraes Caetano Camargo
[3]
;
Roberto Mitsuyoshi Hiramoto
[4]
;
Elcio de Souza Leal
[5]
;
Lucia Maria Almeida Braz
[6]
;
José Angelo Lauletta Lindoso
Total Authors: 7
|
| Document type: | Journal article |
| Source: | Revista do Instituto de Medicina Tropical de São Paulo; v. 65, 2023-10-20. |
| Abstract | |
ABSTRACT Leishmania infantum is a protozoan that causes visceral leishmaniasis (VL) in the Americas and some regions of Europe. The disease is mainly characterized by hepatosplenomegaly and fever, and can be fatal. Factors related to the host and parasite can contribute to the transmission of Leishmania and the clinical outcome. The intraspecific genetic variability of L. infantum strains may be one of these factors. In this study, we evaluated the genetic variability of L. infantum obtained from bone marrow smear slides from patients in the Sao Paulo State, Brazil. For this, the minicircle of the kDNA hypervariable region was used as target by Sanger sequencing. By analyzing the similarity of the nucleotides and the maximum likelihood tree (Fasttree), we observed a high similarity (98%) among samples. Moreover, we identified four different profiles of L. infantum. In conclusion, L. infantum strains from Sao Paulo State, Brazil, showed low diversity measured by minicircle of the kDNA hypervariable region. (AU) | |
| FAPESP's process: | 18/05758-2 - Analysis of polymorphisms of Leishmania (L.) infantum chagasi, through the microsatellite technique, in samples from bone marrow from patients from the State of São Paulo, with visceral leishmaniasis |
| Grantee: | Vinícius Alves de Lima |
| Support Opportunities: | Scholarships in Brazil - Scientific Initiation |
| FAPESP's process: | 16/03165-9 - Coinfection Leishmania/HIV-AIDS: Evaluation of prevalence of coinfection and analysis of genotype from Leishmania (Leishmania) infantum chagasi. |
| Grantee: | José Angelo Lauletta Lindoso |
| Support Opportunities: | Regular Research Grants |