SARS-CoV-2 shedding, infectivity, and evolution in an immunocompromised adult patient

Author(s):Show less -

Maria Cassia Mendes-Correa ^[1] ; Fábio de Rose Ghilardi ^[2] ; Matias Chiarastelli Salomão ; Lucy Santos Villas-Boas ^[4] ; Anderson Vicente de Paula ^[5] ; Heuder Gustavo Oliveira Paiao ^[6] ; Antonio Charlys da Costa ^[7] ; Tânia Regina Tozetto-Mendoza ^[8] ; Wilton Freire ^[9] ; Flavia Cristina Silva Sales ^[10] ; Ingra Morales Claro ; Ester Cerdeira Sabino ^[12] ; Nuno Rodrigues Faria ; Steven Sol Witkin

Affiliation:Show less -

^[1] Universidade de São Paulo. Faculdade de Medicina. Instituto de Medicina Tropical de São Paulo - Brasil

^[2] Universidade de São Paulo. Faculdade de Medicina. Instituto de Medicina Tropical de São Paulo - Brasil

^[4] Universidade de São Paulo. Faculdade de Medicina. Instituto de Medicina Tropical de São Paulo - Brasil

^[5] Universidade de São Paulo. Faculdade de Medicina. Instituto de Medicina Tropical de São Paulo - Brasil

^[6] Universidade de São Paulo. Faculdade de Medicina. Instituto de Medicina Tropical de São Paulo - Brasil

^[7] Universidade de São Paulo. Faculdade de Medicina. Instituto de Medicina Tropical de São Paulo - Brasil

^[8] Universidade de São Paulo. Faculdade de Medicina. Instituto de Medicina Tropical de São Paulo - Brasil

^[9] Universidade de São Paulo. Faculdade de Medicina. Instituto de Medicina Tropical de São Paulo - Brasil

^[10] Universidade de São Paulo. Faculdade de Medicina. Instituto de Medicina Tropical de São Paulo - Brasil

^[12] Universidade de São Paulo. Faculdade de Medicina. Instituto de Medicina Tropical de São Paulo - Brasil

• Document type: Journal article
• Source: Revista do Instituto de Medicina Tropical de São Paulo; v. 66, 2024-05-13.

Abstract

ABSTRACT This study aimed to provide further insight into the evolutionary dynamics of SARS-CoV-2 by analyzing the case of a 40-year-old man who had previously undergone autologous hematopoietic stem cell transplantation due to a diffuse large B-cell lymphoma. He developed a persistent SARS-CoV-2 infection lasting at least 218 days and did not manifest a humoral immune response to the virus during this follow-up period. Whole-genome sequencing and viral cultures confirmed a persistent infection with a replication-positive virus that had undergone genetic variation for at least 196 days after symptom onset. (AU)

• FAPESP's process: 18/14389-0 - Brazil-UK Centre for Arbovirus Discovery, Diagnosis, Genomics and Epidemiology (CADDE)
• Grantee: Ester Cerdeira Sabino
• Support Opportunities: Research Projects - Thematic Grants
• FAPESP's process: 20/05623-0 - SARS-CoV2 detection, in different biological specimens, among people infected with this virus
• Grantee: Maria Cássia Jacintho Mendes Corrêa
• Support Opportunities: Regular Research Grants