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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

The association of testosterone, sleep, and sexual function in men and women

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Andersen, Monica L. [1] ; Alvarenga, Tathiana F. [1] ; Mazaro-Costa, Renata [2] ; Hachul, Helena C. [1, 3] ; Tufik, Sergio [1]
Total Authors: 5
[1] Univ Fed Sao Paulo, Dept Psychobiol, BR-04024002 Sao Paulo - Brazil
[2] Univ Fed Goias, Dept Ciencias Fisiol, Goiania, Go - Brazil
[3] Univ Fed Sao Paulo, Dept Ginecol, BR-04024002 Sao Paulo - Brazil
Total Affiliations: 3
Document type: Review article
Source: Brain Research; v. 1416, p. 80-104, OCT 6 2011.
Web of Science Citations: 62

Testosterone has been the focus of several investigations and review studies in males, but few have addressed its effects on sleep and sexual function, despite evidence of its androgenic effects on circadian activity in both sexes. Studies have been conducted to understand how sleeping increases (and how waking decreases) testosterone levels and how this rhythm can be related to sexual function. This review addresses the inter-relationships among testosterone, sexual function and sleep, including sleep-disordered breathing in both sexes, specifically its effects related to sleep deprivation. In addition, hormonal changes in testosterone that occur in the gonadal and adrenal axis with obstructive sleep apnea and other conditions of chronic sleep deprivation, and which consequently affect sexual life, have also been explored. Nevertheless, hormone-associated sleep disruptions occur across a lifetime, particularly in women. The association between endogenous testosterone and sex, sleep and sleep disturbances is discussed, including the results of clinical trials as well as animal model studies. Evidence of possible pathophysiological mechanisms underlying this relationship is also described. Unraveling the associations of sex steroid hormone concentrations with sleep and sexual function may have clinical implications, as sleep loss reduces testosterone levels in males, and low sex steroid hormone concentrations have been associated with sexual dysfunction. (C) 2011 Elsevier B.V. All rights reserved. (AU)

FAPESP's process: 09/14206-4 - Effect of sleep deprivation and restriction on reproductive function in male rats
Grantee:Monica Levy Andersen
Support type: Regular Research Grants
FAPESP's process: 09/01030-5 - Effect of sleep deprivation and sleep restriction on the reproductive function of male rats
Grantee:Tathiana Aparecida Fernandes de Alvarenga
Support type: Scholarships in Brazil - Doctorate