| Full text | |
| Author(s): |
de Farias, Natalia Oliveira
;
Rodrigues, Amanda Rocha
;
Botelho, Marina Tenorio
;
Magalhaes, Gabriel Rampazzo
;
Raisanen, Riikka
;
Freeman, Harold S.
;
Umbuzeiro, Gisela de Aragao
Total Authors: 7
|
| Document type: | Journal article |
| Source: | Food and Chemical Toxicology; v. 189, p. 8-pg., 2024-05-22. |
| Abstract | |
Emodin is an anthraquinone secondary metabolite produced by several species of plants and fungi. Emodin is known for its pharmacological versatility, and, in the textile industry, for its good dyeing properties. However, its use in the textile industry can result in the formation and disposal of large volumes of wastewater. Emodin mutagenicity has been shown in bacteria and in human cells, but little is known about its possible toxic, genotoxic, or mutagenic effects in aquatic organisms. We have evaluated the eco/genotoxicity of emodin to aquatic organisms. Emodin was toxic to Daphnia similis (EC50 = 130 mu g L-1) and zebrafish embryos (LC50 = 25 mu g L-1). No toxicity was observed for Raphidocelis subcapitata, Ceriodaphnia dubia, or Parhyale hawaiensis. Additional biochemistry/molecular studies are needed to elucidate the toxic/mutagenic pathways of emodin in aquatic organisms. The PNEC value for emodin was 0.025 mu g L-1. In addition to mutagenicity in the Salmonella/ microsome assay, emodin was mutagenic in the micronucleus assay in the amphipod P. hawaiensis. Among the anthraquinone dyes tested to date, natural or synthetic, emodin was the most toxic to aquatic species. (AU) | |
| FAPESP's process: | 20/04628-8 - ToxBioColour: toxicology of bio-based colourants for a sustainable environment |
| Grantee: | Gisela de Aragão Umbuzeiro |
| Support Opportunities: | Regular Research Grants |
| FAPESP's process: | 21/06369-2 - Eco/genotoxicity assessment of a modified natural dye for sustainable processes |
| Grantee: | Gabriel Rampazzo Magalhães |
| Support Opportunities: | Scholarships in Brazil - Master |
| FAPESP's process: | 23/07768-3 - Toxicity and mutagenicity of the natural dye alizarin |
| Grantee: | Amanda Rocha Rodrigues |
| Support Opportunities: | Scholarships in Brazil - Scientific Initiation |
| FAPESP's process: | 22/04482-9 - Developing the marine amphipod Parhyale hawaiensis as a new platform for germ cells mutagenicity assessment |
| Grantee: | Marina Tenório Botelho |
| Support Opportunities: | Scholarships in Brazil - Post-Doctoral |