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In vivo genotoxicity of the natural dye emodin using an aquatic organism

Grant number: 20/06112-9
Support type:Scholarships in Brazil - Scientific Initiation
Effective date (Start): July 01, 2020
Effective date (End): June 30, 2021
Field of knowledge:Engineering - Sanitary Engineering
Principal researcher:Gisela de Aragão Umbuzeiro
Grantee:Gabriel Rampazzo Magalhães
Home Institution: Faculdade de Tecnologia (FT). Universidade Estadual de Campinas (UNICAMP). Limeira , SP, Brazil

Abstract

Dyes are produced in large quantities annually and, as they have toxic properties, they become an environmental problem when disposed in water bodies. Studies have shown that, in addition to altering the quality of water bodies, certain dyes can produce mutagenic and genotoxic effects in aquatic organisms. Emodin is an anthraquinone obtained from plants and fungi, which has been used as a dye of natural origin. After undergoing the AMES test, emodin has been shown to be mutagenic. Damage to individual cells can be analyzed with the comet assay, which is a simple, fast and low cost method. The marine amphipod Parhyale hawaiensis has a circumtropical distribution and has shown promise in toxicity tests and genetic studies. Thus, the present project aims to evaluate the in vivo genotoxicity of the natural dye emodin using the Parhyale hawaiensis model. This project is part of the BioColour project, an international project in which new natural dyes are studied, under the supervision of Prof. Dr. Gisela de Aragão Umbuzeiro.

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