| Full text | |
| Author(s): |
Singulani, Monique Patricio
;
Ferreira, Ana Flavia Fernandes
;
Figueroa, Paulina Sepulveda
;
Cuyul-Vasquez, Ivan
;
Talib, Leda Leme
;
Britto, Luiz Roberto
;
Forlenza, Orestes Vicente
Total Authors: 7
|
| Document type: | Journal article |
| Source: | AGEING RESEARCH REVIEWS; v. 95, p. 20-pg., 2024-02-24. |
| Abstract | |
The role of lithium as a possible therapeutic strategy for neurodegenerative diseases has generated scientific interest. We systematically reviewed and meta-analyzed pre-clinical and clinical studies that evidenced the neuroprotective effects of lithium in Alzheimer's (AD) and Parkinson's disease (PD). We followed the PRISMA guidelines and performed the systematic literature search using PubMed, EMBASE, Web of Science, and Cochrane Library. A total of 32 articles were identified. Twenty-nine studies were performed in animal models and 3 studies were performed on human samples of AD. A total of 17 preclinical studies were included in the meta-analysis. Our analysis showed that lithium treatment has neuroprotective effects in diseases. Lithium treatment reduced amyloid-beta and tau levels and significantly improved cognitive behavior in animal models of AD. Lithium increased the tyrosine hydroxylase levels and improved motor behavior in the PD model. Despite fewer clinical studies on these aspects, we evidenced the positive effects of lithium in AD patients. This study lends further support to the idea of lithium's therapeutic potential in neurodegenerative diseases. (AU) | |
| FAPESP's process: | 20/02109-3 - Involvement of TRPM2 channel in neurodegeneration and microglial activation in a Parkinson's Disease model induced by 6-hydroxydopamine |
| Grantee: | Ana Flávia Fernandes Ferreira |
| Support Opportunities: | Scholarships in Brazil - Doctorate |
| FAPESP's process: | 18/07366-4 - Purine and kinin receptors as targets of study and therapeutic interventions in neurological diseases |
| Grantee: | Alexander Henning Ulrich |
| Support Opportunities: | Research Projects - Thematic Grants |
| FAPESP's process: | 21/06378-1 - Analysis of the involvement of lithium in mitochondrial markers in Alzheimer's Disease |
| Grantee: | Monique Patricio Singulani |
| Support Opportunities: | Scholarships in Brazil - Post-Doctoral |
| FAPESP's process: | 14/50873-3 - INCT 2014: National Institute of Biomarkers in Neuropsychiatry |
| Grantee: | Wagner Farid Gattaz |
| Support Opportunities: | Research Projects - Thematic Grants |