| Full text | |
| Author(s): |
Felippotti, Tatiana Tocchini
[1]
;
dos Reis Ferreira, Celio Marcos
[1]
;
de Freitas, Renato Leonardo
[1]
;
de Oliveira, Rithiele Cristina
[1]
;
de Oliveira, Ricardo
[1]
;
Paschoalin-Maurin, Tatiana
[1]
;
Coimbra, Norberto Cysne
[1]
Total Authors: 7
|
| Affiliation: | [1] Univ Sao Paulo, FMRP, Lab Neuroanat & Neuropsicobiol, Ribeirao Preto Med Sch, Dept Farmacol, BR-14049900 Ribeirao Preto, SP - Brazil
Total Affiliations: 1
|
| Document type: | Journal article |
| Source: | Epilepsy & Behavior; v. 22, n. 2, p. 165-177, OCT 2011. |
| Web of Science Citations: | 15 |
| Abstract | |
The postictal state is generally followed by antinociception. It is known that connections between the dorsal raphe nucleus, the periaqueductal gray matter, and the locus coeruleus, an important noradrenergic brainstem nucleus, are involved in the descending control of ascending nociceptive pathways. The aim of the present study was to determine whether noradrenergic mechanisms in the locus coeruleus are involved in postictal antinociception. Yohimbine (an alpha(2)-receptor antagonist) or propranolol (a beta-receptor antagonist) was microinjected unilaterally into the locus coeruleus, followed by intraperitoneal administration of pentylenetetrazole (PTZ), a noncompetitive antagonist that blocks GABA-mediated Cl(-) influx. Although the administration of both yohimbine and propranolol to the locus coeruleus/subcoeruleus area resulted in a significant decrease in tonic or tonic clonic seizure-induced antinociception, the effect of yohimbine restricted to the locus coeruleus was more distinct compared with that of propranolol, possibly because of the presynaptic localization of alpha(2)-noradrenergic receptors in locus coeruleus neurons. These effects were related to the modulation of noradrenergic activity in the locus coeruleus. Interestingly, microinjections of noradrenaline into the locus coeruleus also decrease the postictal antinociception. The present results suggest that the mechanism underlying postictal antinociception involves both alpha(2)- and beta-noradrenergic receptors in the locus coeruleus, although the action of noradrenaline on these receptors causes a paradoxical effect, depending on the nature of the local neurotransmission. (C) 2011 Elsevier Inc. All rights reserved. (AU) | |
| FAPESP's process: | 02/01496-5 - Estudo do envolvimento do núcleo magno da rafe, do núcleo gigantocelular e núcleo pré-tectal anterior, e de receptores opióides, mu, kappa e delta serotininérgicos 5-HT2A/2C e noradrenérgicos alfa e beta na analgesia pós-ictal: um estudo neuroanatômico e neuropsicofisiológico em um modelo experimental de epilepsia |
| Grantee: | Norberto Cysne Coimbra |
| Support Opportunities: | Regular Research Grants |
| FAPESP's process: | 03/05256-1 - Caracterizacao de receptores serotoninergicos na analgesia pos-ictal: envolvimento do nucleo dorsal da rafe. |
| Grantee: | Renato Leonardo de Freitas |
| Support Opportunities: | Scholarships in Brazil - Master |
| FAPESP's process: | 05/02989-3 - Estudo do envolvimento de vias colinérgicas que conectam o núcleo pedúnculo pontino tegmentar a núcleos monoaminérgicos do sistema endógeno de inibição de dor na analgesia pós-ictal |
| Grantee: | Rithiele Cristina de Oliveira |
| Support Opportunities: | Scholarships in Brazil - Doctorate |
| FAPESP's process: | 96/08574-9 - Estudo de processos antinociceptivos pos-ictais em modelos experimentais de epilepsia. |
| Grantee: | Norberto Cysne Coimbra |
| Support Opportunities: | Regular Research Grants |
| FAPESP's process: | 01/03752-6 - Estudo do envolvimento de receptores m-opioides, colinérgicos muscarínicos e nicotínicos e serotonérgicos 5-HT2/1C na analgesia pós-ictal |
| Grantee: | Renato Leonardo de Freitas |
| Support Opportunities: | Scholarships in Brazil - Scientific Initiation |
| FAPESP's process: | 09/17258-5 - Study of the involvement of nitrergic system and of glutamatergic and cannabinoid-mediated neurotransmission from the medial prefrontal cortex in the analgesia induced by elaborated escape reactions evoked by GABAergic blockade in the medial hypothalamus |
| Grantee: | Renato Leonardo de Freitas |
| Support Opportunities: | Scholarships in Brazil - Post-Doctoral |
| FAPESP's process: | 03/09129-4 - Estudo do envolvimento dos receptores opioides mu 1 e dos corpos quadrigemeos na analgesia pos-ictal. |
| Grantee: | Tatiana Tocchini Felippotti |
| Support Opportunities: | Scholarships in Brazil - Master |
| FAPESP's process: | 08/09897-5 - Psychopharmacological study of opioid disinhibitory and GABAergic inhibitory links between the amygdaloid complex and the substantia nigra, pars lateralis: Role on fear eliciated by electrical and chemical stimulation of the inferior colliculus |
| Grantee: | Ricardo de Oliveira |
| Support Opportunities: | Scholarships in Brazil - Doctorate |