In vitro Evaluation of the Antileishmanial and Antischistosomal Activities of p-Coumaric Acid Prenylated Derivatives

Author(s)

Vieira, Tatiana M. ; Barco, Julia G. ; Paula, Lucas A. L. ; Felix, Paulo C. A. ; Bastos, Jairo K. ; Magalhaes, Lizandra G. ; Crotti, Antonio E. M.

• Document type: Journal article
• Source: CHEMISTRY & BIODIVERSITY; v. 21, n. 5, p. 6-pg., 2024-04-12.

Abstract

We have evaluated eight p-coumaric acid prenylated derivatives in vitro for their antileishmanial activity against Leishmania amazonensis promastigotes and their antischistosomal activity against Schistosoma mansoni adult worms. Compound <bold>7</bold> ((E)-3,4-diprenyl-4-isoprenyloxycinnamic alcohol) was the most active against L. amazonensis (IC50=45.92 mu M) and S. mansoni (IC50=64.25 mu M). Data indicated that the number of prenyl groups, the presence of hydroxyl at C9, and a single bond between C7 and C8 are important structural features for the antileishmanial activity of p-coumaric acid prenylated derivatives. (AU)

• FAPESP's process: 17/04138-8 - Attainment of chemical, analytical, biological, pharmacological and technological studies to fill the gaps on the development of Brazilian propolis sector
• Grantee: Jairo Kenupp Bastos
• Support Opportunities: Research Projects - Thematic Grants
• FAPESP's process: 19/11700-0 - Evaluation of the antimicrobial and antiparasitic activities of Artepillin C and its derivatives and study of their gas-phase fragmentation reactions using tandem mass spectrometry
• Grantee: Tatiana Manzini Vieira
• Support Opportunities: Scholarships in Brazil - Doctorate