| Full text | |
| Author(s): |
Verissimo, Nathalia Vieira Porphirio
;
Mussagy, Cassamo Usemane
;
Bento, Heitor Buzetti Simoes
;
Pereira, Jorge Fernando Brandao
;
Santos-Ebinuma, Valeria de Carvalho
Total Authors: 5
|
| Document type: | Journal article |
| Source: | BIOTECHNOLOGY ADVANCES; v. 71, p. 22-pg., 2024-01-16. |
| Abstract | |
Biopharmaceuticals have allowed the control of previously untreatable diseases. However, their low solubility and stability still hinder their application, transport, and storage. Hence, researchers have applied different compounds to preserve and enhance the delivery of biopharmaceuticals, such as ionic liquids (ILs) and deep eutectic solvents (DESs). Although the biopharmaceutical industry can employ various substances for enhancing formulations, their effect will change depending on the properties of the target biomolecule and environmental conditions. Hence, this review organized the current state-of-the-art on the application of ILs and DESs to stabilize biopharmaceuticals, considering the properties of the biomolecules, ILs, and DESs classes, concentration range, types of stability, and effect. We also provided a critical discussion regarding the potential utilization of ILs and DESs in pharmaceutical formulations, considering the restrictions in this field, as well as the advantages and drawbacks of these substances for medical applications. Overall, the most applied IL and DES classes for stabilizing biopharmaceuticals were cholinium-, imidazolium-, and ammonium-based, with cholinium ILs also employed to improve their delivery. Interestingly, dilute and concentrated ILs and DESs solutions presented similar results regarding the stabilization of biopharmaceuticals. With additional investigation, ILs and DESs have the potential to overcome current challenges in biopharmaceutical formulation. (AU) | |
| FAPESP's process: | 21/06686-8 - Biotechnological process for the development of natural colorants from microbial sources for industrial application: phase II |
| Grantee: | Valéria de Carvalho Santos Ebinuma |
| Support Opportunities: | Program for Research on Bioenergy (BIOEN) - Young Investigators Grants - Phase 2 |
| FAPESP's process: | 23/01368-3 - Stabilization and encapsulation of natural colorants and application in the development of packaging and cosmetics |
| Grantee: | Valéria de Carvalho Santos Ebinuma |
| Support Opportunities: | Regular Research Grants |
| FAPESP's process: | 18/06908-8 - Development of sustainable nanomaterials for the purification of antileukemic drugs |
| Grantee: | Valéria de Carvalho Santos Ebinuma |
| Support Opportunities: | Regular Research Grants |
| FAPESP's process: | 23/10479-3 - Stabilization and encapsulation of natural colorants and application in the development of packaging and cosmetics |
| Grantee: | Nathalia Vieira Porphirio Veríssimo |
| Support Opportunities: | Scholarships in Brazil - Support Program for Fixating Young Doctors |