Quality control of the paracetamol drug by chemometrics and imaging spectroscopy in the near infrared region

Author(s)

Baptistao, Mariana ^[1] ; de Carvalho Rocha, Werickson Fortunato ^[2] ; Poppi, Ronei Jesus ^{[1, 3]}

Affiliation

^[1] Univ Estadual Campinas, UNICAMP, Inst Chem, BR-13083970 Campinas, SP - Brazil

^[2] Natl Inst Metrol Standardizat & Ind Qual, Directorate Ind & Sci Metrol, Div Chem Metrol, BR-25250020 Rio De Janeiro - Brazil

^[3] Natl Inst Sci & Technol INCI Bioanalyt, BR-12130839 Campinas, SP - Brazil

• Document type: Journal article
• Source: Journal of Molecular Structure; v. 1002, n. 1-3, p. 167-171, SEP 14 2011.
• Web of Science Citations: 10

Abstract

In this work, it was used imaging spectroscopy and chemometric tools for the development and analysis of paracetamol and excipients in pharmaceutical formulations. It was also built concentration maps to study the distribution of the drug in the tablets surface. Multivariate models based on PLS regression were developed for paracetamol and excipients concentrations prediction. For the construction of the models it was used 31 samples in the tablet form containing the active principle in a concentration range of 30.0-90.0% (w/w) and errors below to 5% were obtained for validation samples. Finally, the study of the distribution in the drug was performed through the distribution maps of concentration of active principle and excipients. The analysis of maps showed the complementarity between the active principle and excipients in the tablets. The region with a high concentration of a constituent must have, necessarily, absence or low concentration of the other one. Thus, an alternative method for the paracetamol drug quality monitoring is presented. (C) 2011 Elsevier B.V. All rights reserved. (AU)

• FAPESP's process: 06/07309-3 - Novel analytical strategies for studies involving biomolecules
• Grantee: Elias Ayres Guidetti Zagatto
• Support Opportunities: Research Projects - Thematic Grants