Automated multistep synthesis of 2-pyrazolines in continuous flow

Author(s)

Labes, Ricardo ; Pastre, Julio C. ; Ingham, Richard J. ; Battilocchio, Claudio ; Marcon, Henrique M. ; Damiao, Mariana C. F. C. B. ; Tran, Duc N. ; Ley, Steven V.

• Document type: Journal article
• Source: REACTION CHEMISTRY & ENGINEERING; v. 9, n. 3, p. 8-pg., 2023-11-09.

Abstract

The rapid multistep synthesis of 2-pyrazolines from aldehydes via [3 + 2] cycloaddition of unstabilised diazo species and mono and di-substituted alkenes is reported. The development encompasses semi-continuous and fully continuous methods, including a fully automated compound library generation. A graphical interface was developed for the automation control, making it more accessible for chemists without coding experience. The synthesis of 2-pyrazolines from aldehydes via cycloaddition of unstabilised diazo species and alkenes is reported, including automated library generation and graphical interface for reaction control. (AU)

• FAPESP's process: 14/25770-6 - New frontiers in cross-coupling reactions promoted by palladium: combining enantioselective catalysis, C-H activations, new materials and in flux reactions aiming at high efficiency and sustainability in synthetic processes
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• FAPESP's process: 15/18572-6 - Continuous flow synthesis of 3-thio-1,2,4-triazoles and biological evaluation
• Grantee: Mariana Celestina Frojuello Costa Bernstorff Damião
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• FAPESP's process: 14/26378-2 - Development of methodologies and synthetic processes employing a new technological platform: micro and meso reactor assisted synthesis of natural products and derivatives with potential pharmacological activity
• Grantee: Júlio Cezar Pastre
• Support Opportunities: Research Grants - Young Investigators Grants
• FAPESP's process: 20/11578-7 - Enabling technologies allied to green chemistry: synthesis of high value-added compounds from biomass derivatives
• Grantee: Júlio Cezar Pastre
• Support Opportunities: Program for Research on Bioenergy (BIOEN) - Regular Program Grants
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• Grantee: Henrique Magri Marçon
• Support Opportunities: Scholarships in Brazil - Master