| Full text | |
| Author(s): Show less - |
da Silva, Anielly Sarana
;
de Campos, Gabriel Montenegro
;
Altizani, Gabriela Marengone
;
Barros, Alice Chagas
;
Junqueira, Dennis Maletich
;
Kashima, Simone
;
Sampaio, Sandra Coccuzzo
;
Elias, Maria Carolina
;
Giovanetti, Marta
;
Scrideli, Carlos Alberto
;
Slavov, Svetoslav Nanev
Total Authors: 11
|
| Document type: | Journal article |
| Source: | VIRUS RESEARCH; v. 350, p. 5-pg., 2024-10-11. |
| Abstract | |
Human Pegivirus-1, typically regarded as a commensal virus, exhibits high prevalence in humans. Its frequency and impact on oncologic pediatric patients with febrile neutropenia (FN), a frequent chemotherapy complication, remains unexplored. In this study, we assessed HPgV-1 RNA prevalence in pediatric patients experiencing FN. Blood samples were collected from 30 children, 15 presenting FN and 15 comprising a control group of either undergoing treatment or in remission. Overall, HPgV-1 RNA was detected in 23.3 % of samples (26.7 % among FN patients and 20.0% among those under treatment or in remission). Phylogenetic analysis unveiled HPgV-1 genotype 2 predominance among these samples, the most prevalent strain circulating in Brazil. Our findings prompt crucial inquiries into the role of HPgV-1 RNA in FN: is it an incidental finding and if it can influences this clinical entity? Further investigation is imperative to elucidate HPgV-1 implications in vulnerable patients cohorts, potentially informing new approaches and understanding viral dynamics in immunocompromised populations. (AU) | |
| FAPESP's process: | 22/14958-0 - Molecular diagnosis and next-generation sequencing for emerging viral infections in different clinical samples |
| Grantee: | Marlon Breno Zampieri Lima |
| Support Opportunities: | Scholarships in Brazil - Technical Training Program - Technical Training |
| FAPESP's process: | 17/23205-8 - Evaluation of the impact of emerging and reemerging viruses in the field of hemotherapy and stem cell transplantation by multiple-research approach |
| Grantee: | Svetoslav Nanev Slavov |
| Support Opportunities: | Research Grants - Young Investigators Grants |
| FAPESP's process: | 22/00910-6 - Development and application of bioinformatic pipelines for metagenomic analysis of clinical samples |
| Grantee: | Gabriel Montenegro de Campos |
| Support Opportunities: | Scholarships in Brazil - Scientific Initiation |
| FAPESP's process: | 21/11944-6 - Continuous improvement of vaccines: Center for Viral Surveillance and Serological Assessment (CeVIVAS) |
| Grantee: | Sandra Coccuzzo Sampaio Vessoni |
| Support Opportunities: | Research Grants - Science Centers for Development |