Immunology of Kidney Disease

Author(s)

Foresto-Neto, Orestes ; Menezes-Silva, Luisa ; Leite, Jefferson Antonio ; Andrade-Silva, Magaiver ; Camara, Niels Olsen Saraiva

• Document type: Journal article
• Source: ANNUAL REVIEW OF IMMUNOLOGY; v. 42, p. 27-pg., 2024-01-01.

Abstract

The immune system and the kidneys are closely related. Immune components mediate acute kidney disease and are crucial to the progression of chronic kidney disease. Beyond its pathogenic functions, the immune system supports immunological homeostasis in healthy kidneys. The kidneys help maintain immune equilibrium by removing metabolic waste products and toxins, thereby limiting local and systemic inflammation. In this review, we describe the close relationship between the immune system and the kidneys. We discuss how the imbalance in the immune response can be deleterious to the kidneys and how immunomodulation can be important in preventing end-stage renal disease. In addition, recent tools such as in silico platforms and kidney organoids can help unveil the relationship between immune cells and kidney homeostasis. (AU)

• FAPESP's process: 22/03740-4 - Sensing podocytes: connecting extra and intracellular worlds to orchestrate renal fate
• Grantee: Niels Olsen Saraiva Câmara
• Support Opportunities: Regular Research Grants
• FAPESP's process: 17/05264-7 - Cell metabolism, microbiota and immune system: new paradigms in renal diseases physiopathology
• Grantee: Niels Olsen Saraiva Câmara
• Support Opportunities: Research Projects - Thematic Grants
• FAPESP's process: 21/06748-3 - The role of gut HIF-1 signaling in kidney-gut crosstalk in kidney IRI
• Grantee: Niels Olsen Saraiva Câmara
• Support Opportunities: Regular Research Grants
• FAPESP's process: 19/02893-9 - The hypoxia-inducible factor 1 alpha (HIF-1 alpha) and the metabolism of tubular epithelial cells and podocytes in the development and progression of experimental kidney disease
• Grantee: Orestes Foresto Neto
• Support Opportunities: Scholarships in Brazil - Post-Doctoral
• FAPESP's process: 21/03192-4 - Metabolism and B lymphocytes: effects of caloric restriction on the mitochondrial dynamics of B-1 cells
• Grantee: Luísa Menezes Silva
• Support Opportunities: Scholarships in Brazil - Doctorate
• FAPESP's process: 22/13289-8 - Interface between DNA repair mechanisms and metabolism in the regulation of differentiation and function of CD4+ T cells
• Grantee: Jefferson Antonio Leite
• Support Opportunities: Scholarships in Brazil - Post-Doctoral
• FAPESP's process: 20/04592-3 - The role of the intracellular DNA sensor, AIM2, and signaling molecules, STING and MAVS, in proximal tubular epithelial cell metabolism in kidney fibrosis development
• Grantee: Magaiver Andrade Silva
• Support Opportunities: Scholarships in Brazil - Post-Doctoral