In Situ Preparation of Dehydrodieugenol-Loaded Silver Nanoparticles and their Antischistosomal Activity

Author(s)

Oliveira, Larissa V. F. ; Camilo, Fernanda F. ; Soares, Marisi G. ; Cajas, Rayssa A. ; Cirino, Maria E. ; de Moraes, Josue ; Lago, Joao Henrique G.

• Document type: Journal article
• Source: CHEMISTRY & BIODIVERSITY; v. 21, n. 3, p. 8-pg., 2024-02-21.

Abstract

Schistosomiasis is a major neglected disease that imposes a substantial worldwide health burden, affecting approximately 250 million people globally. As praziquantel is the only available drug to treat schistosomiasis, there is a critical need to identify new anthelmintic compounds, particularly from natural sources. To enhance the activity of different natural products, one potential avenue involves its combination with silver nanoparticles (AgNP). Based on this approach, a one-step green method for the in situ preparation of dehydrodieugenol (DHDG) by oxidation coupling reaction using silver and natural eugenol is presented. AgNP formation was confirmed by UV-Vis spectroscopy due to the appearance of the surface plasmon resonance (SPR) band at 430 nm which is characteristic of silver nanoparticles. The nanoparticles were spherical with sizes in the range of 40 to 50 nm. Bioassays demonstrated that the silver nanoparticles loaded with DHDG exhibited significant anthelmintic activity against Schistosoma mansoni adult worms without toxicity to mammalian cells and an in vivo animal model (Caenorhabditis elegans), contributing to the development of new prototypes based on natural products for the treatment of schistosomiasis. image (AU)

• FAPESP's process: 21/07971-8 - Preparation of analogues of natural products combined with silver nanoparticles and their application against resistant bacteria Mycobacterium abscessus
• Grantee: Larissa Verena Figueiredo de Oliveira
• Support Opportunities: Scholarships in Brazil - Post-Doctoral
• FAPESP's process: 21/08987-5 - Cellulose membranes as support for nanomaterials: preparation and properties evaluation
• Grantee: Fernanda Ferraz Camilo
• Support Opportunities: Regular Research Grants
• FAPESP's process: 23/12447-1 - Searching for specialized metabolites from Brazilian floristic biodiversity as drug candidates for neglected tropical diseases
• Grantee: João Henrique Ghilardi Lago
• Support Opportunities: BIOTA-FAPESP Program - Regular Research Grants
• FAPESP's process: 21/02789-7 - Search for bioactive metabolites with antiparasitic action in plant species from Atlantic Forest and Cerrado regions - a chemical, phenotypical, and metabolomic approach
• Grantee: João Henrique Ghilardi Lago
• Support Opportunities: BIOTA-FAPESP Program - Regular Research Grants