Effect of Co, Cu, and Zn ions on the bioactivity and antibacterial properties of a borate bioactive glass

Author(s)

dos Santos, Veronica Ribeiro ; Campos, Tiago Moreira Bastos ; Anselmi, Caroline ; Thim, Gilmar Patrocinio ; Bottino, Marco C. ; Borges, Alexandre Luiz Souto ; Triches, Eliandra de Sousa

• Document type: Journal article
• Source: Journal of Non-Crystalline Solids; v. 622, p. 12-pg., 2023-09-25.

Abstract

In this work, our original glycol thermal method was applied to obtain borate bioactive glasses of the 45B5 composition (46.1 B2O3 - 26.9 CaO - 24.4 NaO - 2.6 P2O5, mol%) doped with therapeutic ions Co2+, Cu2+, and Zn2+ aiming toward wound healing applications. The structural analysis performed demonstrated the successful vitreous network obtention, while the apatite mineralization assay exhibited fast conversion into hydroxyapatite (HA, Ca5(PO4)3(OH)). Cell viability findings performed with human keratinocytes revealed an absence of cytotoxicity at concentrations below 0.5 mg/mL at day 1, manifested after 3-and 7-days, demonstrating a time -and dose-dependence in vitro outcome. The inhibition halo assay confirmed the antibacterial activity of all glasses against S. aureus. Considering the set of properties evaluated (i.e., bioactivity, cytocompatibility, and antibac-terial activity), the synthesized glasses demonstrate potential for wound healing applications when incorporated into nanofibers, hydrogels, and dermal patches. (AU)

• FAPESP's process: 20/12874-9 - Infiltration graded by glass in an experimental composite based on whiskers of alumina and zircônia: development, microstructural characterization and optical and mechanical properties
• Grantee: Tiago Moreira Bastos Campos
• Support Opportunities: Scholarships in Brazil - Post-Doctoral
• FAPESP's process: 19/19594-4 - 3D pritting of bioactive and resorbable scaffolds by robocasting: synthesis, processing and antibacterial activity
• Grantee: Eliandra de Sousa Trichês
• Support Opportunities: Regular Research Grants
• FAPESP's process: 19/10877-3 - PHBV nanofibers containing sol-gel derived bioactive borate glasses doped with therapeutic ions for tissue regeneration
• Grantee: Verônica Ribeiro dos Santos
• Support Opportunities: Scholarships in Brazil - Doctorate
• FAPESP's process: 22/12217-3 - Silver-strontium-co-doped mesoporous bioactive glass functionalized 3D-printed B-tricalcium phosphate scaffolds for improving bone regeneration
• Grantee: Eliandra de Sousa Trichês
• Support Opportunities: Scholarships abroad - Research
• FAPESP's process: 20/12507-6 - Development and characterization of wollastonite cement for bone tissue engineering
• Grantee: Gilmar Patrocínio Thim
• Support Opportunities: Regular Research Grants