| Full text | |
| Author(s): Show less - |
Tofani, Patricia Silva
;
Maximo, Roberta de Oliveira
;
Cochar-Soares, Natalia
;
Ramirez, Paula Camila
;
Luiz, Mariane Marques
;
Lima, Sara Souza
;
da Silva, Thais Barros Pereira
;
de Souza, Thales Batista
;
Silveira, Leticia Coelho
;
Guandalini, Valdete Regina
;
Steptoe, Andrew
;
de Oliveira, Cesar
;
Alexandre, Tiago da Silva
Total Authors: 13
|
| Document type: | Journal article |
| Source: | AGING & MENTAL HEALTH; v. N/A, p. 9-pg., 2024-08-13. |
| Abstract | |
ObjectivesInvestigate whether the coexistence of pain and depressive symptoms is a risk factor for cognitive decline in individuals aged 50 or older.MethodLongitudinal trajectory study involving 4,718 participants from the English Longitudinal Study of Ageing (ELSA). Joint pain was self-reported, and intensity was classified as mild, moderate/intense. Depressive symptoms were investigated using the Centre for Epidemiologic Studies Depression Scale (CES-D-8 >= 4). The sample was divided into six groups: no pain and no depression (NP/NDe), mild pain and no depression (MP/NDe), moderate/intense pain and no depression (M-IP/NDe), no pain and depression (NP/De), mild pain and depression (MP/De), and moderate/intense pain and depression (M-IP/De). The outcome of interest was performance in memory, executive function, and global cognition. Generalised linear mixed models were used to analyse performance in the cognitive domains and global cognition score as a function of pain and depressive symptoms during 12 years of follow-up.ResultsOver time, individuals with M-IP/De had a greater memory decline (-0.038 SD/year, 95%CI: -0.068 to -0.007) and the global cognition score (-0.033 SD/year, 95%CI: -0.063 to -0.002) than those with NP/NDe.ConclusionThe coexistence of moderate/intense pain and depressive symptoms is a risk factor for the decline of global cognition and memory. (AU) | |
| FAPESP's process: | 18/13917-3 - Musculoskeletal aging: metabolic and functional repercussions and mortality risk in people aged 50 and older |
| Grantee: | Tiago da Silva Alexandre |
| Support Opportunities: | Research Grants - Young Investigators Grants |