Electrospun Polylactic Acid/Polyethylene Glycol/ Silicate-Chlorinated Bioactive Glass Composite Scaffolds for Potential Bone Regeneration

Author(s)

de Souza, Joyce R. ; Kukulka, Elisa C. ; Kito, Leticia T. ; Alves, Mariana de Sa ; dos Santos, Veronica R. ; Triches, Eliandra S. ; Vasconcellos, Luana M. R. ; Thim, Gilmar P. ; Campos, Tiago M. B. ; Borges, Alexandre L. S.

• Document type: Journal article
• Source: POLYMERS FOR ADVANCED TECHNOLOGIES; v. 35, n. 11, p. 11-pg., 2024-11-01.

Abstract

The integration of bioglass with polymers in tissue engineering scaffolds holds promise for enhancing bone regeneration. This study explores the fabrication and characterization of composite scaffolds comprising polylactic acid (PLA)/polyethylene glycol (PEG) fibers incorporated with silicate-chlorinated bioglasses (45S5 and 58S). Electrospinning was utilized to produce the scaffolds, followed by physical-chemical and in vitro evaluations. Scanning electron microscopy (SEM) revealed uniform fiber formation, with bioglass incorporation observed in the composite groups. Bioglass incorporation led to a significant reduction in fiber diameter. Thermogravimetric analysis (TGA) estimated bioglass content, with 58S exhibiting the highest incorporation. Contact angle measurements indicated enhanced hydrophilicity in bioglass-containing groups. In vitro, bioactivity assessment in simulated body fluid (SBF) demonstrated apatite formation potential and the pH variance indicates a slightly alkaline to neutral condition. Cell culture studies revealed robust cellular adhesion and metabolic activity across all groups, with no cytotoxic effects observed. Overall, these findings suggest the potential of PLA/PEG bioglass composite scaffolds for bone tissue engineering applications. (AU)

• FAPESP's process: 19/19594-4 - 3D pritting of bioactive and resorbable scaffolds by robocasting: synthesis, processing and antibacterial activity
• Grantee: Eliandra de Sousa Trichês
• Support Opportunities: Regular Research Grants
• FAPESP's process: 19/10877-3 - PHBV nanofibers containing sol-gel derived bioactive borate glasses doped with therapeutic ions for tissue regeneration
• Grantee: Verônica Ribeiro dos Santos
• Support Opportunities: Scholarships in Brazil - Doctorate
• FAPESP's process: 20/12507-6 - Development and characterization of wollastonite cement for bone tissue engineering
• Grantee: Gilmar Patrocínio Thim
• Support Opportunities: Regular Research Grants
• FAPESP's process: 20/12874-9 - Infiltration graded by glass in an experimental composite based on whiskers of alumina and zircônia: development, microstructural characterization and optical and mechanical properties
• Grantee: Tiago Moreira Bastos Campos
• Support Opportunities: Scholarships in Brazil - Post-Doctoral