Unraveling the Applicability of LbL Coatings for Drug Delivery in Dental Implant-Related Infection Treatment

Author(s)

Pereira, MartaMaria Alves ; Piazza, Rodolfo ; Santana, Amanda Paino ; Barao, Valentim Adelino Ricardo ; Malheiros, Samuel Santana ; van den Beucken, Jeroen J. J. P. ; de Molon, Rafael Scaf ; de Avila, Erica Dorigatti

• Document type: Journal article
• Source: ACS BIOMATERIALS SCIENCE & ENGINEERING; v. N/A, p. 20-pg., 2024-11-30.

Abstract

Peri-implantitis is an inflammatory condition caused by bacterial biofilms adhered on dental implant surfaces that cause progressive tissue destruction from the host's inflammatory response. The adverse effects of peri-implantitis progression can go beyond just losing the implant. This highlights the importance of implementing strategies to stabilize disease in the short term. Layer-by-layer (LbL) assembly is a promising avenue in the field of peri-implantitis management due to its applicability with a variety of substances, in addition to being an easy, versatile, and flexible process for multilayer formation to act directly in the affected site. In this Review, our objective is to offer comprehensive chemical and biological insights into the LbL system, clarifying its specific application as antimicrobial coatings, with concern for the physical site and purpose. Additionally, we delve deeper into the concepts of onset and progression of peri-implantitis, aiming to elucidate the precise indications for employing the LbL system as a coating for implant abutments in peri-implantitis treatment. Finally, we correlate the chemical composition of the LbL system with its functionality while also addressing the challenges posed by the uncontrolled environment of the oral cavity, which ultimately restricts its clinical applicability. (AU)

• FAPESP's process: 18/20719-3 - A novel antimicrobial drug-delivery coating for percutaneous implant devices
• Grantee: Érica Dorigatti de Avila
• Support Opportunities: Research Grants - Young Investigators Grants
• FAPESP's process: 21/10762-1 - Vascular regenerative MAA-based material film on antimicrobial [PAA/PLL]10/TC/anionic B-CD coating for percutaneous implants devices
• Grantee: Marta Maria Alves Pereira
• Support Opportunities: Scholarships in Brazil - Doctorate (Direct)
• FAPESP's process: 22/16267-5 - Antimicrobial and osteogenic surface development by electrodeposition of polypyrrole film on titanium surfaces treated by plasma electrolytic oxidation: a multifunctional coating for dental implants
• Grantee: Valentim Adelino Ricardo Barão
• Support Opportunities: Regular Research Grants
• FAPESP's process: 23/15750-7 - Unveiling the therapeutic potential of Tanshinone-IIa sulfonate in the prevention and treatment of experimental periodontitis in mice
• Grantee: Rafael Scaf de Molon
• Support Opportunities: Regular Research Grants
• FAPESP's process: 21/09434-0 - A novel antimicrobial drug-delivery coating for percutaneous implant devices
• Grantee: Érica Dorigatti de Avila
• Support Opportunities: Scholarships in Brazil - Young Researchers