| Full text | |
| Author(s): Show less - |
Adolpho, Leticia Faustino
;
Gomes, Maria Paula Oliveira
;
Freitas, Gileade Pereira
;
Bighetti-Trevisan, Rayana Longo
;
Ramos, Jaqueline Isadora Reis
;
Campeoti, Gabriela Hernandes
;
Zatta, Guilherme Crepi
;
Almeida, Adriana Luisa Goncalves
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Tarone, Adriana Gadioli
;
Marostica-Junior, Mario Roberto
;
Rosa, Adalberto Luiz
;
Beloti, Marcio Mateus
Total Authors: 12
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| Document type: | Journal article |
| Source: | BIOLOGY-BASEL; v. 13, n. 7, p. 12-pg., 2024-07-01. |
| Abstract | |
Simple Summary Therapies to prevent osteoporosis are relevant since it is one of the most common non-communicable human diseases in the world and the most prevalent bone disorder in adults. Jaboticaba is a small, round fruit with white pulp and purple peel that concentrates compounds that may have therapeutic applications. Since jaboticaba peel extract (JPE) enhances the activity of osteoblasts (the cells that form bone) under osteoporotic conditions, we hypothesized that JPE prevents the development of osteoporosis induced by the removal of the ovaries. Ovariectomized rats were treated with either JPE (30 mg/kg of body weight) or its vehicle for 90 days, starting 7 days after the ovariectomy. JPE attenuated ovariectomy-induced bone loss due to its ability to prevent the imbalance between osteoblast and adipocyte (the cells that produce bone and fat, respectively) differentiation. These data indicate the potential therapeutic use of JPE to prevent osteoporosis.Abstract Therapies to prevent osteoporosis are relevant since it is one of the most common non-communicable human diseases in the world and the most prevalent bone disorder in adults. Since jaboticaba peel extract (JPE) added to the culture medium enhanced the osteogenic potential of mesenchymal stem cells (MSCs) derived from osteoporotic rats, we hypothesized that JPE prevents the development of ovariectomy-induced osteoporosis. Ovariectomized rats were treated with either JPE (30 mg/kg of body weight) or its vehicle for 90 days, starting 7 days after the ovariectomy. Then, the femurs were subjected to microcomputed tomography and histological analyses, and the osteoblast and adipocyte differentiation of MSCs was evaluated. JPE attenuated ovariectomy-induced bone loss, as evidenced by higher bone volume/total volume and trabecular number, along with lower trabecular separation and bone marrow adiposity. These protective effects of JPE on bone tissue are due to its ability to prevent the imbalance between osteoblast and adipocyte differentiation of MSCs, since, compared with MSCs derived from ovariectomized rats treated with vehicle, MSCs treated with JPE exhibited higher gene and protein expression of osteogenic markers and extracellular matrix mineralization, as well as lower gene expression of adipogenic markers. These data highlight the potential therapeutic use of JPE to prevent osteoporosis. (AU) | |
| FAPESP's process: | 22/09493-9 - Metabolomic in vitro studies of fruit anthocyanins for understanding its mechanisms of action against Obesity |
| Grantee: | Juliano Lemos Bicas |
| Support Opportunities: | Regular Research Grants |
| FAPESP's process: | 17/12622-7 - Cell therapy: potential of mesenchymal stem cells, VEGF-A and BMP-9 to regenerate bone tissue |
| Grantee: | Adalberto Luiz Rosa |
| Support Opportunities: | Research Projects - Thematic Grants |