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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Influence of third-generation oral contraceptives on the complexity analysis and symbolic dynamics of heart rate variability

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Author(s):
Rebelo, Ana Cristina [1, 2] ; Tamburus, Nayara [1] ; Salviati, Mariana [1] ; Celante, Vanessa [1] ; Takahashi, Anielle [2] ; de Sa, Marcos Felipe [3] ; Catai, Aparecida [2] ; Silva, Ester [1, 2]
Total Authors: 8
Affiliation:
[1] Univ Metodista Piracicaba, Dept Physiotherapy, Coll Hlth Sci, Sao Paulo - Brazil
[2] Univ Fed Sao Carlos, Lab Cardiovasc Physiotherapy, Dept Physiotherapy, BR-13565905 Sao Carlos, SP - Brazil
[3] Univ Sao Paulo, Dept Obstet & Gynaecol, Coll Med, BR-14049 Ribeirao Preto - Brazil
Total Affiliations: 3
Document type: Journal article
Source: EUROPEAN JOURNAL OF CONTRACEPTION AND REPRODUCTIVE HEALTH CARE; v. 16, n. 4, p. 289-297, AUG 2011.
Web of Science Citations: 6
Abstract

Objective To evaluate the influence of oral contraceptives (OCs) containing 20 mu mu g ethinylestradiol (EE) and 150 mu mu g gestodene (GEST) on the autonomic modulation of heart rate (HR) in women. Methods One-hundred and fifty-five women aged 24 +/-+/- 2 years were divided into four groups according to their physical activity and the use or not of an OC: active-OC, active-non-OC (NOC), sedentary-OC, and sedentary-NOC. The heart rate was registered in real time based on the electrocardiogram signal for 15 minutes, in the supine-position. The heart rate variability (HRV) was analysed using Shannon's entropy (SE), conditional entropy (complexity index {[}CInd] and normalised CInd {[}NCI]), and symbolic analysis (0V%, 1V%, 2LV%, and 2ULV%). For statistical analysis the Kruskal-Wallis test with Dunn post hoc and the Wilcoxon test (p < 0.05 was considered significant) were applied. Results Treatment with this COC caused no significant changes in SE, CInd, NCI, or symbolic analysis in either active or sedentary groups. Active groups presented higher values for SE and 2ULV%, and lower values for 0V% when compared to sedentary groups (p < 0.05). Conclusion HRV patterns differed depending on life style; the non-linear method applied was highly reliable for identifying these changes. The use of OCs containing 20 mu mu g EE and 150 mu mu g GEST does not influence HR autonomic modulation. (AU)