Advanced search
Start date
Betweenand


Mycobacterium tuberculosis spoligotypes and drug-resistant characterization from Beira compared to genotypes circulating in Mozambique

Full text
Author(s):
Pala Anselmo, Livia Maria ; Conceicao, Emilyn Costa ; Namburete, Evangelina ; Feliciano, Cinara ; Spindola, Silvana ; Sola, Christophe ; Bollela, Valdes Roberto
Total Authors: 7
Document type: Journal article
Source: Revista da Sociedade Brasileira de Medicina Tropical; v. 52, p. 4-pg., 2019-01-01.
Abstract

Introduction: Mozambique is one of three countries with high prevalence of tuberculosis (TB), TB/human immunodeficiency virus coinfection, and multidrug-resistant TB. We aimed to describe Mycobacterium tuberculosis spoligotypes circulating among drug resistant (DR) strains from Beira, Mozambique comparing them with genotypes in the country. Methods: We performed spoligotyping of 79 M. tuberculosis suspected of DR-TB compared all spoligotype patterns published on the international database and PubMed. Results: Both in Beira and Mozambique (n=578), the main clades were Latin-American-Mediterranean, East-African-Indian, Beijing and T, with no extensively DR TB cases. Conclusions: Beira and Mozambique share the same population genetic structure of M. tuberculosis. (AU)

FAPESP's process: 15/13333-3 - Molecular epidemiology of multidrug resistant tuberculosis through whole genome sequencing
Grantee:Valdes Roberto Bollela
Support Opportunities: Regular Research Grants