Do nocturnal asthma attacks influence sleep parameters and inflammatory markers? A cross-sectional population-based study

Author(s)

Souza, Maingredy Rodrigues ; Rosa, Daniela Santoro ; Alvarenga, Tathiana A. ; Morelhao, Priscila K. ; Tufik, Sergio ; Andersen, Monica L.

• Document type: Journal article
• Source: Sleep and Breathing; v. 28, n. 2, p. 9-pg., 2023-10-14.

Abstract

PurposeTo evaluate the effects of nocturnal asthma on sleep parameters and inflammatory markers according to the severity of the condition in participants in the Sao Paulo Epidemiologic Sleep Study (EPISONO).MethodsData from the 2007 and 2018 editions of the EPISONO study were utilized. Subjects completed validated sleep and respiratory questionnaires, underwent nocturnal polysomnography and spirometry tests, and provided blood samples for the assessment of inflammatory parameters.ResultsOf 72 participants (67% women), 53% (n = 38) had intermittent nocturnal asthma symptoms and 47% (n = 34) had persistent asthma (mild, moderate, and severe). Individuals with persistent nocturnal symptoms had a higher body mass index (BMI), were more likely to have respiratory symptoms, and had worse lung function, a higher apnea-hypopnea index (AHI), and higher desaturation index than individuals with intermittent nocturnal symptoms. Positive associations were identified between nocturnal asthma and obstructive sleep apnea (OSA). A higher frequency of OSA was observed in participants with persistent asthma and participants with OSA were more likely to have persistent than intermittent asthma. However, there were no significant differences between the immunological parameters of those with intermittent or persistent asthma.ConclusionsThis study highlights the relevance of nocturnal symptoms as a valuable indicator of asthma severity. The findings also add to the existing body of evidence linking nocturnal asthma and OSA. (AU)

• FAPESP's process: 20/13467-8 - The relationship between obstructive sleep apnea and its comorbidities with the intestinal microbiome: interface with sexuality and reproductive function
• Grantee: Monica Levy Andersen
• Support Opportunities: Research Projects - Thematic Grants
• FAPESP's process: 21/13004-0 - Development of subunit vaccines against SARS-CoV-2 based on the receptor binding domain (RBD)
• Grantee: Daniela Santoro Rosa
• Support Opportunities: Regular Research Grants