A short-term high-sugar diet is an aggravating factor in experimental allergic contact dermatitis

Author(s)

Coelho, Leila F. ; Casaro, Mateus B. ; Ribeiro, Willian R. ; Mendes, Eduardo ; Murata, Gilson ; Xander, Patricia ; Lino-dos-Santos-Franco, Adriana ; Oliveira, Fernando A. ; Ferreira, Caroline M.

• Document type: Journal article
• Source: HELIYON; v. 9, n. 11, p. 10-pg., 2023-11-09.

Abstract

Allergic contact dermatitis (ACD) is an inflammatory skin reaction whose incidence has increased and has been associated with a dietary pattern rich in saturated fats and refined sugars. Considering the increased incidence of ACD and the lack of research about the influence of a short-term high-sugar diet on dermatitis, our aim is to improve understanding of the influence of a high-sugar diet on ACD. We introduced a diet rich in sugar fifteen days before inducing contact dermatitis with oxazolone, in mice, and maintained it until the end of the experiment, which lasted three weeks in total. The dermatitis model increased cholesterol and triglycerides in the liver, and the combination of diet and dermatitis increased weight and worsened liver cholesterol measurements. Furthermore, the high-sugar diet increased the production of IL-6, IFN-gamma and TNF alpha in the skin, which may be involved in the increase in epithelial skin thickness observed in experimental ACD. (AU)

• FAPESP's process: 21/06751-4 - Deciphering the immune mechanism of increased airway allergic disease in menopause
• Grantee: Caroline Marcantonio Ferreira
• Support Opportunities: Research Grants - Young Investigators Grants - Phase 2
• FAPESP's process: 12/50410-8 - Effects of short-chain fatty acids produced by probiotic bacteria in the prophylaxis and treatment of allergic airway inflammation
• Grantee: Caroline Marcantonio Ferreira
• Support Opportunities: Research Grants - Young Investigators Grants
• FAPESP's process: 16/13496-2 - Symbiotic administration's role in the perinatal period in experimental allergic asthma in offspring
• Grantee: Mateus Campos Casaro
• Support Opportunities: Scholarships in Brazil - Scientific Initiation
• FAPESP's process: 19/27245-0 - Relationship between intracellular ATP dynamics and modulation of cytosolic calcium concentration in the neuron
• Grantee: Fernando Augusto de Oliveira Ribeiro
• Support Opportunities: Regular Research Grants