Characterization and stability of solid lipid nanoparticles produced from different fully hydrogenated oils

Author(s)

Stahl, Marcella Aparecida ; Ludtke, Fernanda Luisa ; Grimaldi, Renato ; Gigante, Mirna Lucia ; Ribeiro, Ana Paula Badan

• Document type: Journal article
• Source: Food Research International; v. 176, p. 17-pg., 2023-12-10.

Abstract

The use of lipids from conventional oils and fats to produce solid lipid nanoparticles (SLN) attracting interest from the food industry, since due their varying compositions directly affects crystallization behavior, stability, and particle sizes (PS) of SLN. Thus, this study aimed evaluate the potential of fully hydrogenated oils (hardfats) with different hydrocarbon chain lengths to produce SLN using different emulsifiers. For that, fully hydrogenated palm kern (FHPkO), palm (FHPO), soybean (FHSO), microalgae (FHMO) and crambe (FHCO) oils were used. Span 60 (S60), soybean lecithin (SL), and whey protein isolate (WPI) were used as emulsifiers. The physicochemical characteristics and crystallization properties of SLN were evaluated during 60 days. Results indicates that the crystallization properties were more influenced by the hardfat used. SLN formulated with FHPkO was more unstable than the others, and hardfats FHPO, FHSO, FHMO, and FHCO exhibited the appropriate characteristics for use to produce SLN. Concerning emulsifiers, S60- based SLN showed high instability, despite the hardfat used. SL-based and WPI-based SLN formulations, showed a great stability, with crystallinity properties suitable for food incorporation. (AU)

• FAPESP's process: 16/11261-8 - OILS, FATS AND NANOTECHNOLOGY:DEVELOPMENT OF SOLID LIPID NANOPARTICLES AND NANOSTRUCTURED LIPID CARRIERS FOR INCORPORTATION OF BIOACTIVE LIPOPHILIC COMPOUNDS
• Grantee: Ana Paula Badan Ribeiro
• Support Opportunities: Regular Research Grants
• FAPESP's process: 19/27354-3 - Architecture of colloidal delivery systems: what is the role of structure on the digestibility?
• Grantee: Rosiane Lopes da Cunha
• Support Opportunities: Research Projects - Thematic Grants
• FAPESP's process: 18/03172-0 - Development of nanostructured lipid carriers for incorporation of lipophilic bioactive compounds
• Grantee: Fernanda Luisa Lüdtke
• Support Opportunities: Scholarships in Brazil - Doctorate
• FAPESP's process: 19/05176-6 - Evaluation of in vitro digestibility of nanostructured lipid carriers containing ²-carotene
• Grantee: Fernanda Luisa Lüdtke
• Support Opportunities: Scholarships abroad - Research Internship - Doctorate